Seroatlas · Human Serome Atlas

WHAMM

WASP homolog-associated protein with actin, membranes and microtubules

Also known as: KIAA1971, WHAMM_HUMAN, WHAMM1, WHDC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TF30
Gene
WHAMM
Ensembl
ENSG00000156232
Chromosome
15
Canonical length
809 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

809 residues, UniProt reviewed canonical sequence.

>Q8TF30|WHAMM
     1  MEDEQPDSLE GWVPVREGLF AEPERHRLRF LVAWNGAEGK FAVTCHDRTA QQRRLREGAR
    61  LGPEPEPKPE AAVSPSSWAG LLSAAGLRGA HRQLAALWPP LERCFPRLPP ELDVGGGGAW
   121  GLGLGLWALL WPTRAGPGEA ALQELCGQLE RYLGAAADGC GGATVRDALF PAEGGAADCE
   181  SPREFRERAL RARWVEADAR LRQVIQGHGK ANTMVALMNV YQEEDEAYQE LVTVATMFFQ
   241  YLLQPFRAMR EVATLCKLDI LKSLDEDDLG PRRVVALEKE AEEWTRRAEE AVVSIQDITV
   301  NYFKETVKAL AGMQKEMEQD AKRFGQAAWA TAIPRLEKLQ LMLARETLQL MRAKELCLNH
   361  KRAEIQGKME DLPEQEKNTN VVDELEIQFY EIQLELYEVK FEILKNEEIL LTTQLDSLKR
   421  LIKEKQDEVV YYDPCENPEE LKVIDCVVGL QDDKNLEVKE LRRQCQQLES KRGRICAKRA
   481  SLRSRKDQCK ENHRFRLQQA EESIRYSRQH HSIQMKRDKI KEEEQKKKEW INQERQKTLQ
   541  RLRSFKDKRL AQSVRNTSGS EPVAPNLPSD LSQQMCLPAS HAVSVIHPSS RKTRGVPLSE
   601  AGNVKSPKCQ NCHGNIPVQV FVPVGDQTHS KSSEELSLPP PPPPPPPPPP PPPPPPPPLR
   661  ALSSSSQAAT HQNLGFRAPV KDDQPRPLVC ESPAERPRDS LESFSCPGSM DEVLASLRHG
   721  RAPLRKVEVP AVRPPHASIN EHILAAIRQG VKLKKVHPDL GPNPSSKPTS NRRTSDLERS
   781  IKAALQRIKR VSADSEEDSD EQDPGQWDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WHAMM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 29 nTPM
  • skeletal muscle: 17 nTPM
  • liver: 8.5 nTPM
  • skin: 8.5 nTPM
  • spleen: 8.1 nTPM
  • adipose tissue: 7.4 nTPM

Single-cell type

  • urothelial cells: 98 nCPM
  • ocular epithelial cells: 81 nCPM
  • esophageal apical cells: 81 nCPM
  • neutrophil progenitors: 70 nCPM
  • epididymal basal cells: 70 nCPM
  • nk-cells: 68 nCPM

Immune cell

  • basophil: 2.5 nTPM
  • NK-cell: 2.3 nTPM
  • neutrophil: 1.2 nTPM
  • gdT-cell: 1.1 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • naive B-cell: 1.1 nTPM

Brain region

  • choroid plexus: 20 nTPM
  • cerebellum: 14 nTPM
  • white matter: 14 nTPM
  • cerebral cortex: 12 nTPM
  • medulla oblongata: 11 nTPM
  • basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
-0.18
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WHAMM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WHAMM as an antibody target. Whether an autoantibody or antibody against WHAMM could matter depends on whether native WHAMM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WHAMM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WHAMM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WHAMM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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