Seroatlas · Human Serome Atlas

RGS7BP

Regulator of G-protein signaling 7-binding protein

Also known as: R7BP, R7BP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6MZT1
Gene
RGS7BP
Ensembl
ENSG00000186479
Chromosome
5
Canonical length
257 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q6MZT1|RGS7BP
     1  MSSAPNGRKK RPSRSTRSSI FQISKPPLQS GDWERRGSGS ESAHKTQRAL DDCKMLVQEF
    61  NTQVALYREL VISIGDVSVS CPSLRAEMHK TRTKGCEMAR QAHQKLAAIS GPEDGEIHPE
   121  ICRLYIQLQC CLEMYTTEML KSICLLGSLQ FHRKGKEPGG GTKSLDCKIE ESAETPALED
   181  SSSSPVDSQQ HSWQVSTDIE NTERDMREMK NLLSKLRETM PLPLKNQDDS SLLNLTPYPL
   241  VRRRKRRFFG LCCLISS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS7BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 22 nTPM
  • fallopian tube: 7.4 nTPM
  • seminal vesicle: 7 nTPM
  • basal ganglia: 5 nTPM
  • prostate: 5 nTPM
  • cerebellum: 4.9 nTPM

Single-cell type

  • brain inhibitory neurons: 181 nCPM
  • thyrotrophs: 136 nCPM
  • retinal amacrine cells: 135 nCPM
  • retinal ganglion cells: 128 nCPM
  • brain excitatory neurons: 125 nCPM
  • adrenal medulla cells: 85 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 106 nTPM
  • basal ganglia: 70 nTPM
  • thalamus: 60 nTPM
  • white matter: 59 nTPM
  • hippocampal formation: 54 nTPM
  • cerebellum: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
1.02
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS7BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS7BP as an antibody target. Whether an autoantibody or antibody against RGS7BP could matter depends on whether native RGS7BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS7BP is annotated at the cell surface, where native RGS7BP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RGS7BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RGS7BP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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