Seroatlas · Human Serome Atlas

GPR179

Probable G-protein coupled receptor 179

Also known as: GP179_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PRD1
Gene
GPR179
Canonical length
2367 aa
Protein class
Human disease related genes, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

No narrative summary is available for GPR179 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

2367 residues, UniProt reviewed canonical sequence.

>Q6PRD1|GPR179
     1  MGTRGAVMPP PMWGLLGCCF VCAWALGGPR PIRSLPPLSS QVKPGSVPMQ VPLEGAEAAL
    61  AYLYSGDAQQ LSQVNCSERY EARGAGAMPG LPPSLQGAAG TLAQAANFLN MLLQANDIRE
   121  SSVEEDVEWY QALVRSVAEG DPRVYRALLT FNPPPGASHL QLALQATRTG EETILQDLSG
   181  NWVQEENPPG DLDTPALKKR VLTNDLGSLG SPKWPQADGY VGDTQQVRLS PPFLECQEGR
   241  LRPGWLITLS ATFYGLKPDL SPEVRGQVQM DVDLQSVDIN QCASGPGWYS NTHLCDLNST
   301  QCVPLESQGF VLGRYLCRCR PGFYGASPSG GLEESDFQTT GQFGFPEGRS GRLLQCLPCP
   361  EGCTSCMDAT PCLVEEAAVL RAAVLACQAC CMLAIFLSML VSYRCRRNKR IWASGVVLLE
   421  TVLFGFLLLY FPVFILYFKP SVFRCIALRW VRLLGFAIVY GTIILKLYRV LQLFLSRTAQ
   481  RSALLSSGRL LRRLGLLLLP VLGFLAVWTV GALERGIQHA PLVIRGHTPS GRHFYLCHHD
   541  RWDYIMVVAE LLLLCWGSFL CYATRAVLSA FHEPRYMGIA LHNELLLSAA FHTARFVLVP
   601  SLHPDWTLLL FFFHTHSTVT TTLALIFIPK FWKLGAPPRE EMVDEVCEDE LDLQHSGSYL
   661  GSSIASAWSE HSLDPGDIRD ELKKLYAQLE VHKTKEMAAN NPHLPKKRGS SCQGLGRSFM
   721  RYLAEFPEAL ARQHSRDSGS PGHGSLPGSS RRRLLSSSLQ EPEGTPALHK SRSTYDQRRE
   781  QDPPLLDSLL RRKLAKKASR TESRESVEGP PALGFRSASA HNLTVGERLP RARPASLQKS
   841  LSVASSREKA LLMASQAYLE ETYRQAKERE ERKKAKAAMA SLVRRPSARR LERPRGAPLS
   901  APPSPAKSSS VDSSHTSGRL HEEARRRLPH PPIRHQVSTP ILALSGGLGE PRMLSPTSTL
   961  APALLPALAP TPAPALAPVP VSPQSPNLLT YICPWENAEL PAKQENVPQE GPSGPERGHH
  1021  SPAPARARLW RALSVAVEKS RAGENEMDAE DAHHQREAND VDEDRPKIFP KSHSLKAPVQ
  1081  QGSMRSLGLA IKALTRSRST YREKESVEES PEGQNSGTAG ESMGAPSRSP RLGRPKAVSK
  1141  QAALIPSDDK ESLQNQQNAH TSRMLQVCQR EGSREQEDRG RRMTQGLGER KAERAGKTGL
  1201  AMLRQVSRDK NIKQSKETPV GWQELPKAGL QSLGSADHRV AEVCPWEVTE SETRQPDSGN
  1261  KAEICPWETS EGAPESRALR QDPGDSQKKR GEARGKSEPI DVVPMMRKKP ERLVREQEAV
  1321  CPWESADRGG LSPGSAPQDP GRIRDKSEAG DSVEARKVEK PGWEAAGPEA HTPDITKAEP
  1381  CPWEASEGGE DGKPAQEAVK DLPQEKQKTR KATFWKEQKP GGDLESLCPW ESTDFRGPSA
  1441  VSIQAPGSSE CSGSLGSGIA EVCLWEAGDA PAIQKAEICP WELDDNVMGQ EMLSLGTGRE
  1501  SLQEKEKASR KGSFGEMGEQ TVKAVQKLSQ QQESVCPRES TVPGHSSPCL DNSSSKAGSQ
  1561  FLCNGGSRAT QVCPQEDLRP EAQEATPAKT EICPWEVNER TREEWTSAQV PRGGESQKDK
  1621  EKMPGKSEIE DVTAWEKPEG QIQKQEAVGP WESVDPGSFS PQPRPQDTER PQTLLQMSGS
  1681  VGSKAADICP LDVEENLTAG KAEICPWEVG AGAGEERALG AEAIRKSPND TGKVSADLGP
  1741  RERAVTAPEK PQKPTPEWEV ACPWGSVGPG ACSQHPGTLD ADGPKAGFQE LDHMGCRPGE
  1801  VCPWEAQEAA TSEKAKICPW EVSEGTTGKG LDQKAGSESA EQREKALEKG RLTSLGEDVS
  1861  KGMAKLCQQQ ETICIWENKD LRESPAQAPK ISDLPSSMSS EVAEGHSLEA TEKGDLRQDP
  1921  KTGSFPEHIT QEKAPAADTE EFTTEDGEKT SHELQSVCPW ETTAPADSVS HLDRQRPDQP
  1981  KASSQRLVST GGRAADVCPW DVPDAGVYKS DSSAKAETCP WEVTERIPVK GVSRQDGKGD
  2041  SQEEKGRAPE KSEPKGVPVQ KKPEMADFRQ QEAVCPWESQ DGKGLSPQPA PDASDRSRGS
  2101  SEAAGSVETR VAEVCLWEVV EAPSAKKAEI CPWEAGGGAA EEGEQERESQ GQGEMFLQKA
  2161  GPGGTEEHFS KAAAKPREQE AVCPGEGTGS GGLLPQSGAL DPELKVSPKE AGSMGSRMAE
  2221  LCQWEITDPE GNKIKGTMAD ICPGEETGVP SEESGLLALT ATRREFFPTA PEKPLCLLVH
  2281  GPLDHFFPES KIPCPKVSRP ASTFTLEGVR ELQGPSGLEP RTSLAPEPSL QEAESQSSSL
  2341  TEDSGQVAFE AQYEEFTPPT VYPWDWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR179 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • retina: 13 nTPM
  • hypothalamus: 1.5 nTPM
  • basal ganglia: 1.3 nTPM
  • cerebellum: 1.3 nTPM
  • cerebral cortex: 1.3 nTPM
  • testis: 0.5 nTPM

Single-cell type

  • other brain neurons: 3.8 nCPM
  • brain inhibitory neurons: 2.5 nCPM
  • retinal bipolar cells: 2.3 nCPM
  • brain excitatory neurons: 1.8 nCPM
  • astrocytes: 0.8 nCPM
  • oligodendrocyte progenitor cells: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 5.3 nTPM
  • spinal cord: 4.2 nTPM
  • basal ganglia: 4.1 nTPM
  • midbrain: 3.8 nTPM
  • cerebral cortex: 3.7 nTPM
  • pons: 2.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPR179.

Disease | AllUniProt

Conditions GPR179 is implicated in, by any mechanism.

  • Night blindness, congenital stationary, 1E (CSNB1E) MIM:614565

Disease | GeneticClinVar

46 pathogenic / likely-pathogenic of 1,521 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
0.84
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR179 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR179 as an antibody target. Whether an autoantibody or antibody against GPR179 could matter depends on whether native GPR179 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR179 is annotated at the cell surface, where native GPR179 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR179 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPR179. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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