Seroatlas · Human Serome Atlas

MEIOC

Meiosis-specific coiled-coil domain-containing protein MEIOC

Also known as: C17orf104, FLJ35848, MEIOC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2RUB1
Gene: MEIOC
Ensembl: ENSG00000180336
Chromosome: 17
Canonical length: 952 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions

OverviewNCBI Gene

Predicted to be involved in several processes, including germ cell development; germline cell cycle switching, mitotic to meiotic cell cycle; and meiosis I. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

952 residues, UniProt reviewed canonical sequence.

>A2RUB1|MEIOC
     1  MEVRRGDTCP RPHPSGLREE GLEPKVAFPG GANRCWNLGA DAGSRLTDVF GSVMLTGSAS
    61  FYDCYTSQSE DNVDLRQTYT PFSSTEYSSS VDSSLFCAPW STYGDDIKQP SNSQISIKNR
   121  IQTERNDYGS ETDLYGLVSN ILEEQDKSQP YFAEGTCSSN LKSVWPMNTS RFADHHDLLT
   181  ETKRPIDTVI SQQAFYSDES VSAMEKQYLR NSNLTPQQKI DELHHGFTGL DLEEQWMYPS
   241  RSDHSNCHNI QTNDTAKTTF QEYPLIKNCF TPQTGLSDIM KESGVDIYHY GRDRICTKGL
   301  EAPLQQKRAE MFLSQFNRYN ENVDYCRYPE YVHPNKAKLN KCSNFSVQDS KKLANGTPET
   361  PTVEADTYTK LFQVKPANQK KMEETIPDQQ NFTFPKTTPH LTEKQFAKEA VFTADFGLTS
   421  EYGLKPHTAC PANDFANVTE KQQFAKPDPP HSEYFKSVNL LSNSATSSGG INLNRPTWMN
   481  VQTKNNTPIP YRNQGNLMKL NSHLSAASKG SNHSSDFPQL SSTNLTPNSN LFQKYCQENP
   541  SAFSSFDFSY SGAERIQSVN HIEGLTKPGE ENLFKLVTDK KIKQPNGFCD NYSAQKYGII
   601  ENVNKHNFQA KPQSGHYDPE EGPKHLDGLS QNTYQDLLES QGHSNSHRTR GGDNSRVNRT
   661  QVSCFSNNYM MGDLRHNQCF QQLGSNGFPL RSTHPFGHSV VPLLDSYDLL SYDDLSHLYP
   721  YFNMMYGDNS FSGLMPTFGF QRPIKTRSGP ASELHIRLEE CCEQWRALEK ERKKTELALA
   781  KNYPGKKVSS TNNTPVPRLT SNPSRVDRLI VDELRELARV VTLLGKMERL RSSLLHASIS
   841  TALDRHLESI HIVQSRRKDE IVNASNRQRQ GVPRCQDDRD VFALASAIKE MCVATRKTRT
   901  ALWCALQMTL PKTASTADVV KPLQDTVNCE DKVHESINSS NPMNQRGETN KH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEIOC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

testis: 45 nTPM
cerebellum: 3.2 nTPM
skeletal muscle: 2.1 nTPM
cerebral cortex: 1.5 nTPM
retina: 1.4 nTPM
basal ganglia: 1.1 nTPM

Single-cell type

late spermatids: 930 nCPM
early spermatids: 349 nCPM
early primary spermatocytes: 303 nCPM
late primary spermatocytes: 139 nCPM
differentiating spermatogonia: 80 nCPM
cardiomyocytes: 76 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
naive B-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM

Brain region

cerebellum: 5.8 nTPM
cerebral cortex: 5.4 nTPM
hippocampal formation: 4.9 nTPM
white matter: 4.8 nTPM
amygdala: 4.5 nTPM
basal ganglia: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Meiosis-specific coiled-coil domain-containing protein MEIOC
Meiosis-specific coiled-coil domain-containing protein MEIOC

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEIOC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEIOC as an antibody target. Whether an autoantibody or antibody against MEIOC could matter depends on whether native MEIOC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEIOC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEIOC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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