Seroatlas · Human Serome Atlas

PRPF40A

Pre-mRNA-processing factor 40 homolog A

Also known as: PR40A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75400
Gene: PRPF40A
Canonical length: 957 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PRPF40A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

957 residues, UniProt reviewed canonical sequence.

>O75400|PRPF40A
     1  MRPGTGAERG GLMVSEMESH PPSQGPGDGE RRLSGSSLCS GSWVSADGFL RRRPSMGHPG
    61  MHYAPMGMHP MGQRANMPPV PHGMMPQMMP PMGGPPMGQM PGMMSSVMPG MMMSHMSQAS
   121  MQPALPPGVN SMDVAAGTAS GAKSMWTEHK SPDGRTYYYN TETKQSTWEK PDDLKTPAEQ
   181  LLSKCPWKEY KSDSGKPYYY NSQTKESRWA KPKELEDLEG YQNTIVAGSL ITKSNLHAMI
   241  KAEESSKQEE CTTTSTAPVP TTEIPTTMST MAAAEAAAAV VAAAAAAAAA AAAANANAST
   301  SASNTVSGTV PVVPEPEVTS IVATVVDNEN TVTISTEEQA QLTSTPAIQD QSVEVSSNTG
   361  EETSKQETVA DFTPKKEEEE SQPAKKTYTW NTKEEAKQAF KELLKEKRVP SNASWEQAMK
   421  MIINDPRYSA LAKLSEKKQA FNAYKVQTEK EEKEEARSKY KEAKESFQRF LENHEKMTST
   481  TRYKKAEQMF GEMEVWNAIS ERDRLEIYED VLFFLSKKEK EQAKQLRKRN WEALKNILDN
   541  MANVTYSTTW SEAQQYLMDN PTFAEDEELQ NMDKEDALIC FEEHIRALEK EEEEEKQKSL
   601  LRERRRQRKN RESFQIFLDE LHEHGQLHSM SSWMELYPTI SSDIRFTNML GQPGSTALDL
   661  FKFYVEDLKA RYHDEKKIIK DILKDKGFVV EVNTTFEDFV AIISSTKRST TLDAGNIKLA
   721  FNSLLEKAEA REREREKEEA RKMKRKESAF KSMLKQAAPP IELDAVWEDI RERFVKEPAF
   781  EDITLESERK RIFKDFMHVL EHECQHHHSK NKKHSKKSKK HHRKRSRSRS GSDSDDDDSH
   841  SKKKRQRSES RSASEHSSSA ESERSYKKSK KHKKKSKKRR HKSDSPESDA EREKDKKEKD
   901  RESEKDRTRQ RSESKHKSPK KKTGKDSGNW DTSGSELSEG ELEKRRRTLL EQLDDDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRPF40A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 77 nTPM
lymph node: 47 nTPM
thymus: 45 nTPM
tonsil: 43 nTPM
testis: 41 nTPM
urinary bladder: 40 nTPM

Single-cell type

erythrocyte progenitors: 331 nCPM
monocyte progenitors: 279 nCPM
megakaryocyte progenitors: 271 nCPM
late primary spermatocytes: 263 nCPM
neutrophil progenitors: 262 nCPM
suprabasal keratinocytes: 246 nCPM

Immune cell

basophil: 76 nTPM
non-classical monocyte: 72 nTPM
eosinophil: 70 nTPM
intermediate monocyte: 67 nTPM
myeloid DC: 61 nTPM
plasmacytoid DC: 55 nTPM

Brain region

cerebellum: 41 nTPM
white matter: 35 nTPM
cerebral cortex: 34 nTPM
medulla oblongata: 34 nTPM
hypothalamus: 33 nTPM
choroid plexus: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.04
gnomAD missense Z: 3.33
DepMap mean gene effect: -1.12
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRPF40A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRPF40A as an antibody target. Whether an autoantibody or antibody against PRPF40A could matter depends on whether native PRPF40A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRPF40A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRPF40A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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