Seroatlas · Human Serome Atlas

ZNF564

Zinc finger protein 564

Also known as: MGC26914, ZN564_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TBZ8
Gene
ZNF564
Ensembl
ENSG00000249709
Chromosome
19
Canonical length
553 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q8TBZ8|ZNF564
     1  MDSVASEDVA VNFTLEEWAL LDPSQKKLYR DVMRETFRNL ACVGKKWEDQ SIEDWYKNQG
    61  RILRNHMEEG LSESKEYDQC GEAFSQILNL NLNKKIPTIV RPCECSLCGK VFMHHSSLSR
   121  HIRSHLGHKP YDYQEYGEKP YKCKQCGKAF SSCQSFRRHE RTHTGEKPYA CPECGKAFIS
   181  LPSVRRHMIK HTGDGPYKCQ ECGKAFDRPS LFQIHERTHT GEKPYECQEC AKAFISLPSF
   241  QRHMIRHTGD GPYKCQECGK AFDRPSLFRI HERTHTGEKP HECKQCGKAF ISFTNFQSHM
   301  IRHTGDGPYK CKVCGRAFIF PSYVRKHERT HTGEKPYECN KCGKTFSSSS NVRTHERTHT
   361  GEKPYECKEC GKAFISLPSV RRHMIKHTGD GPYKCQVCGR AFDCPSSFQI HERTHTGEKP
   421  YECQVCGKAF ISLKRIRKHM ILHTGDGPYK CQVCGKAFDC PSSVRTHERT HTGEKPYECK
   481  ECGKAFNYAS SIRIHERTHT GEKPYECKQC GKTFSYSSSF QRHERAHNGD KPYVKNVGKL
   541  SFITQPSNTC ENE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF564 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
7.5 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 7.5 nTPM
  • thyroid gland: 7.4 nTPM
  • kidney: 7.2 nTPM
  • parathyroid gland: 7.1 nTPM
  • breast: 7 nTPM
  • thymus: 7 nTPM

Single-cell type

  • myosatellite cells: 2.3 nCPM
  • conjunctival goblet cells: 1 nCPM
  • respiratory deuterosomal cells: 1 nCPM
  • salivary duct cells: 1 nCPM
  • corticotrophs: 0.9 nCPM
  • granulosa cells: 0.8 nCPM

Immune cell

  • eosinophil: 19 nTPM
  • basophil: 15 nTPM
  • memory B-cell: 15 nTPM
  • neutrophil: 14 nTPM
  • non-classical monocyte: 13 nTPM
  • gdT-cell: 12 nTPM

Brain region

  • cerebellum: 38 nTPM
  • white matter: 31 nTPM
  • cerebral cortex: 26 nTPM
  • medulla oblongata: 25 nTPM
  • pons: 25 nTPM
  • basal ganglia: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0.36
gnomAD missense Z
1.08
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF564 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF564 as an antibody target. Whether an autoantibody or antibody against ZNF564 could matter depends on whether native ZNF564 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF564 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF564 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF564. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...