Seroatlas · Human Serome Atlas

RPSA2

Small ribosomal subunit protein uS2B

Also known as: RPSA2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A8I5KQE6
Gene: RPSA2
Canonical length: 295 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for RPSA2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>A0A8I5KQE6|RPSA2
     1  MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEHYIYK RKSDGIYIIN LKRTWEKLLL
    61  AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFWEPR
   121  LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR
   181  EVLRMRGTIS REHPWEVMPD LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPSPEFTA
   241  TQPEVADWSE GVQVPSVPIQ QFPTEDWSAQ PATEDWSAAP TAQATEWVGA TTDWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPSA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPSA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPSA2 as an antibody target. Whether an autoantibody or antibody against RPSA2 could matter depends on whether native RPSA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPSA2 is annotated at the cell surface, where native RPSA2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RPSA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...