Seroatlas · Human Serome Atlas

POLDIP2

Polymerase delta-interacting protein 2

Also known as: DKFZP586F1524, PDIP2_HUMAN, PDIP38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2S7
Gene: POLDIP2
Ensembl: ENSG00000004142
Chromosome: 17
Canonical length: 368 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>Q9Y2S7|POLDIP2
     1  MAACTARRAL AVGSRWWSRS LTGARWPRPL CAAAGAGAFS PASTTTTRRH LSSRNRPEGK
    61  VLETVGVFEV PKQNGKYETG QLFLHSIFGY RGVVLFPWQA RLYDRDVASA APEKAENPAG
   121  HGSKEVKGKT HTYYQVLIDA RDCPHISQRS QTEAVTFLAN HDDSRALYAI PGLDYVSHED
   181  ILPYTSTDQV PIQHELFERF LLYDQTKAPP FVARETLRAW QEKNHPWLEL SDVHRETTEN
   241  IRVTVIPFYM GMREAQNSHV YWWRYCIRLE NLDSDVVQLR ERHWRIFSLS GTLETVRGRG
   301  VVGREPVLSK EQPAFQYSSH VSLQASSGHM WGTFRFERPD GSHFDVRIPP FSLESNKDEK
   361  TPPSGLHW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLDIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 256 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 256 nTPM
tongue: 196 nTPM
liver: 163 nTPM
heart muscle: 118 nTPM
adrenal gland: 109 nTPM
kidney: 95 nTPM

Single-cell type

late spermatids: 249 nCPM
esophageal apical cells: 168 nCPM
esophageal suprabasal cells: 167 nCPM
hepatocytes: 157 nCPM
esophageal basal cells: 134 nCPM
extravillous trophoblasts: 126 nCPM

Immune cell

myeloid DC: 60 nTPM
total PBMC: 53 nTPM
memory B-cell: 49 nTPM
classical monocyte: 49 nTPM
intermediate monocyte: 47 nTPM
memory CD8 T-cell: 44 nTPM

Brain region

thalamus: 63 nTPM
hypothalamus: 62 nTPM
midbrain: 60 nTPM
cerebral cortex: 60 nTPM
medulla oblongata: 57 nTPM
choroid plexus: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.41
gnomAD missense Z: 1.94

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLDIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLDIP2 as an antibody target. Whether an autoantibody or antibody against POLDIP2 could matter depends on whether native POLDIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLDIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLDIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...