Plexin family
IPR031148
Definition
Plexins are neuronal receptors for the axon guidance regulators Semaphorins. Semaphorin-plexin interactions play central roles in regulating processes such as neuronal axon guidance, angiogenesis and immune responses. Plexin is activated upon binding of semaphorin to the extracellular region. The GTPase Activating Protein (GAP) domain in the cytoplasmic region mediates intrantracellular signalling PMID:25824683. In mammals, nine plexins have been identified, which are grouped into four subfamilies: Plexin-A1-4, Plexin-B1-3, Plexin-C1, and Plexin-D1 PMID:10520995.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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