Seroatlas · Human Serome Atlas

FSCN1

Fascin

Also known as: FLJ38511, FSCN1_HUMAN, p55, SNL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16658
Gene
FSCN1
Ensembl
ENSG00000075618
Chromosome
7
Canonical length
493 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q16658|FSCN1
     1  MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV
    61  CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR WSLQSEAHRR YFGGTEDRLS
   121  CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA
   181  FQDQRYSVQT ADHRFLRHDG RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL
   241  KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR
   301  DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS NGKFVTSKKN
   361  GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND
   421  GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA
   481  SAETVDPASL WEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSCN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 82 nTPM
  • cerebral cortex: 73 nTPM
  • basal ganglia: 72 nTPM
  • hippocampal formation: 72 nTPM
  • esophagus: 67 nTPM
  • amygdala: 58 nTPM

Single-cell type

  • hofbauer cells: 667 nCPM
  • esophageal basal cells: 212 nCPM
  • basal keratinocytes: 189 nCPM
  • granulosa cells: 148 nCPM
  • extravillous trophoblasts: 142 nCPM
  • suprabasal keratinocytes: 134 nCPM

Immune cell

  • myeloid DC: 2.1 nTPM
  • classical monocyte: 0.8 nTPM
  • total PBMC: 0.7 nTPM
  • neutrophil: 0.4 nTPM
  • intermediate monocyte: 0.2 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • thalamus: 261 nTPM
  • white matter: 256 nTPM
  • cerebral cortex: 235 nTPM
  • basal ganglia: 226 nTPM
  • medulla oblongata: 202 nTPM
  • midbrain: 187 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FSCN1.

Disease | ImmuneIEDB

Conditions an epitope on FSCN1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.87
gnomAD missense Z
1.98
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FSCN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSCN1 as an antibody target. Whether an autoantibody or antibody against FSCN1 could matter depends on whether native FSCN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSCN1 is annotated at the cell surface, where native FSCN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FSCN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FSCN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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