Lysine-specific demethylase 4-like, Tudor domain

Definition

This is the tudor domain found in lysine-specific demethylase 4A-C (KDM4A, also known as JMJD2A-C, respectively). KDM4A/B are histone demethylases that specifically demethylate 'Lys-9' and 'Lys-36' residues of histone H3, while KDM4B specifically demethylates 'Lys-9'. Structure and function analysis indicate that this domain can recognize equally well two unrelated histone peptides, H3K4me3 and H4K20me3, by means of two very different binding mechanisms PMID:18084306. KDM4 belongs to the conserved iron (II)-dependent jumonji-domain demethylase subfamily that is essential during development. Vertebrate KDM4A-C proteins contain a conserved double tudor domain (DTD) [[cite:PMID:27841353], [cite:PMID:35534851]]. This entry also includes PHD finger protein 19 (PHF19), Metal-response element-binding transcription factor 2 (MTF2) and PHD finger protein 1 (PHF1) which are polycomb group (PcG) proteins that specifically binds histone H3 trimethylated at 'Lys-36' and recruits the PRC2 complex PMID:31959557. PHD finger protein 20-like protein 1 negative regulator of proteasomal degradation of a set of methylated proteins PMID:29358331 is also included in this entry.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• KDM4A
• KDM4B
• KDM4C
• MTF2
• PHF1
• PHF19
• PHF20L1