Seroatlas · Human Serome Atlas

RIOX1

Ribosomal oxygenase 1

Also known as: C14orf169, FLJ21802, JMJD9, MAPJD, NO66, RIOX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H6W3
Gene
RIOX1
Ensembl
ENSG00000170468
Chromosome
14
Canonical length
641 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoli rim

OverviewNCBI Gene

Enables peptidyl-histidine dioxygenase activity and protein demethylase activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of osteoblast differentiation; and regulation of DNA repair. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

641 residues, UniProt reviewed canonical sequence.

>Q9H6W3|RIOX1
     1  MDGLQASAGP LRRGRPKRRR KPQPHSGSVL ALPLRSRKIR KQLRSVVSRM AALRTQTLPS
    61  ENSEESRVES TADDLGDALP GGAAVAAVPD AARREPYGHL GPAELLEASP AARSLQTPSA
   121  RLVPASAPPA RLVEVPAAPV RVVETSALLC TAQHLAAVQS SGAPATASGP QVDNTGGEPA
   181  WDSPLRRVLA ELNRIPSSRR RAARLFEWLI APMPPDHFYR RLWEREAVLV RRQDHTYYQG
   241  LFSTADLDSM LRNEEVQFGQ HLDAARYING RRETLNPPGR ALPAAAWSLY QAGCSLRLLC
   301  PQAFSTTVWQ FLAVLQEQFG SMAGSNVYLT PPNSQGFAPH YDDIEAFVLQ LEGRKLWRVY
   361  RPRVPTEELA LTSSPNFSQD DLGEPVLQTV LEPGDLLYFP RGFIHQAECQ DGVHSLHLTL
   421  STYQRNTWGD FLEAILPLAV QAAMEENVEF RRGLPRDFMD YMGAQHSDSK DPRRTAFMEK
   481  VRVLVARLGH FAPVDAVADQ RAKDFIHDSL PPVLTDRERA LSVYGLPIRW EAGEPVNVGA
   541  QLTTETEVHM LQDGIARLVG EGGHLFLYYT VENSRVYHLE EPKCLEIYPQ QADAMELLLG
   601  SYPEFVRVGD LPCDSVEDQL SLATTLYDKG LLLTKMPLAL N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • thymus: 8.7 nTPM
  • bone marrow: 7.4 nTPM
  • liver: 6.4 nTPM
  • tonsil: 6.4 nTPM
  • lymph node: 6.2 nTPM

Single-cell type

  • early spermatids: 28 nCPM
  • hepatocytes: 14 nCPM
  • breast lactating cells: 12 nCPM
  • differentiating spermatogonia: 12 nCPM
  • cytotrophoblasts: 11 nCPM
  • late primary spermatocytes: 11 nCPM

Immune cell

  • MAIT T-cell: 4.3 nTPM
  • gdT-cell: 3.7 nTPM
  • memory CD4 T-cell: 3.6 nTPM
  • eosinophil: 3.4 nTPM
  • naive CD4 T-cell: 3.3 nTPM
  • NK-cell: 3.2 nTPM

Brain region

  • cerebellum: 18 nTPM
  • white matter: 16 nTPM
  • basal ganglia: 15 nTPM
  • hypothalamus: 15 nTPM
  • cerebral cortex: 15 nTPM
  • choroid plexus: 14 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIOX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIOX1 as an antibody target. Whether an autoantibody or antibody against RIOX1 could matter depends on whether native RIOX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIOX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIOX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIOX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...