Seroatlas · Human Serome Atlas

CCR2

C-C chemokine receptor type 2

Also known as: CC-CKR-2, CCR2_HUMAN, CD192, CKR2, CMKBR2, FLJ78302, MCP-1-R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41597
Gene
CCR2
Ensembl
ENSG00000121807
Chromosome
3
Canonical length
374 aa
Protein class
CD markers, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins
Subcellular location
Nucleoli fibrillar center,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>P41597|CCR2
     1  MLSTSRSRFI RNTNESGEEV TTFFDYDYGA PCHKFDVKQI GAQLLPPLYS LVFIFGFVGN
    61  MLVVLILINC KKLKCLTDIY LLNLAISDLL FLITLPLWAH SAANEWVFGN AMCKLFTGLY
   121  HIGYFGGIFF IILLTIDRYL AIVHAVFALK ARTVTFGVVT SVITWLVAVF ASVPGIIFTK
   181  CQKEDSVYVC GPYFPRGWNN FHTIMRNILG LVLPLLIMVI CYSGILKTLL RCRNEKKRHR
   241  AVRVIFTIMI VYFLFWTPYN IVILLNTFQE FFGLSNCEST SQLDQATQVT ETLGMTHCCI
   301  NPIIYAFVGE KFRSLFHIAL GCRIAPLQKP VCGGPGVRPG KNVKVTTQGL LDGRGKGKSI
   361  GRAPEASLQD KEGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • appendix: 23 nTPM
  • spleen: 15 nTPM
  • lymph node: 10 nTPM
  • smooth muscle: 6.3 nTPM
  • duodenum: 6.2 nTPM
  • tonsil: 6.1 nTPM

Single-cell type

  • monocyte progenitors: 88 nCPM
  • pdcs: 73 nCPM
  • monocytes: 65 nCPM
  • plasma cells: 32 nCPM
  • cdc: 23 nCPM
  • macrophages: 11 nCPM

Immune cell

  • basophil: 557 nTPM
  • classical monocyte: 145 nTPM
  • myeloid DC: 144 nTPM
  • plasmacytoid DC: 112 nTPM
  • MAIT T-cell: 85 nTPM
  • total PBMC: 81 nTPM

Brain region

  • medulla oblongata: 0.7 nTPM
  • choroid plexus: 0.6 nTPM
  • spinal cord: 0.6 nTPM
  • white matter: 0.6 nTPM
  • pons: 0.5 nTPM
  • thalamus: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCR2.

Disease | AllUniProt

Conditions CCR2 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 62 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cystic disease of lung

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0.02
gnomAD missense Z
0.03
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCR2 as an antibody target. Whether an autoantibody or antibody against CCR2 could matter depends on whether native CCR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCR2 is annotated at the cell surface, where native CCR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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