ZFPM2

Protein identityUniProt · HPA

UniProt accession

Q8WW38

Gene

ZFPM2

Ensembl

ENSG00000169946

Chromosome

8

Canonical length

1151 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1151 residues, UniProt reviewed canonical sequence.

>Q8WW38|ZFPM2
     1  MSRRKQSKPR QIKRPLEDAI EDEEEECPSE ETDIISKGDF PLEESFSTEF GPENLSCEEV
    61  EYFCNKGDDE GIQETAESDG DTQSEKPGQP GVETDDWDGP GELEVFQKDG ERKIQSRQQL
   121  PVGTTWGPFP GKMDLNNNSL KTKAQVPMVL TAGPKWLLDV TWQGVEDNKN NCIVYSKGGQ
   181  LWCTTTKAIS EGEELIAFVV DFDSRLQAAS QMTLTEGMYP ARLLDSIQLL PQQAAMASIL
   241  PTAIVNKDIF PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDS AHQISSLCPF
   301  PQCTKSFSNA RALEMHLNSH SGVKMEEFLP PGASLKCTVC SYTADSVINF HQHLFSHLTQ
   361  AAFRCNHCHF GFQTQRELLQ HQELHVPSGK LPRESDMEHS PSATEDSLQP ATDLLTRSEL
   421  PQSQKAMQTK DASSDTELDK CEKKTQLFLT NQRPEIQPTT NKQSFSYTKI KSEPSSPRLA
   481  SSPVQPNIGP SFPVGPFLSQ FSFPQDITMV PQASEILAKM SELVHRRLRH GSSSYPPVIY
   541  SPLMPKGATC FECNITFNNL DNYLVHKKHY CSSRWQQMAK SPEFPSVSEK MPEALSPNTG
   601  QTSINLLNPA AHSADPENPL LQTSCINSST VLDLIGPNGK GHDKDFSTQT KKLSTSSNND
   661  DKINGKPVDV KNPSVPLVDG ESDPNKTTCE ACNITFSRHE TYMVHKQYYC ATRHDPPLKR
   721  SASNKVPAMQ RTMRTRKRRK MYEMCLPEQE QRPPLVQQRF LDVANLNNPC TSTQEPTEGL
   781  GECYHPRCDI FPGIVSKHLE TSLTINKCVP VSKCDTTHSS VSCLEMDVPI DLSKKCLSQS
   841  ERTTTSPKRL LDYHECTVCK ISFNKVENYL AHKQNFCPVT AHQRNDLGQL DGKVFPNPES
   901  ERNSPDVSYE RSIIKCEKNG NLKQPSPNGN LFSSHLATLQ GLKVFSEAAQ LIATKEENRH
   961  LFLPQCLYPG AIKKAKGADQ LSPYYGIKPS DYISGSLVIH NTDIEQSRNA ENESPKGQAS
  1021  SNGCAALKKD SLPLLPKNRG MVIVNGGLKQ DERPAANPQQ ENISQNPQHE DDHKSPSWIS
  1081  ENPLAANENV SPGIPSAEEQ LSSIAKGVNG SSQAPTSGKY CRLCDIQFNN LSNFITHKKF
  1141  YCSSHAAEHV K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFPM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

32 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZFPM2.

Disease | AllUniProt

Conditions ZFPM2 is implicated in, by any mechanism.

• Tetralogy of Fallot (TOF) MIM:187500
• Diaphragmatic hernia 3 (DIH3) MIM:610187
• 46,XY sex reversal 9 (SRXY9) MIM:616067
• Conotruncal heart malformations (CTHM) MIM:217095

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 481 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Diaphragmatic hernia 3
• 46,XY sex reversal 9
• Double outlet right ventricle
• ZFPM2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.14

gnomAD pLI

1

gnomAD missense Z

0.21

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• embryonic organ development
• fat cell differentiation
• gonadal mesoderm development
• heart development
• in utero embryonic development
• lung development
• negative regulation of DNA-templated transcription
• negative regulation of fat cell differentiation
• negative regulation of female gonad development
• negative regulation of transcription by RNA polymerase II
• outflow tract septum morphogenesis
• positive regulation of cardiac muscle cell proliferation
• positive regulation of male gonad development
• positive regulation of transcription by RNA polymerase II
• right ventricular cardiac muscle tissue morphogenesis
• vasculogenesis
• ventricular septum morphogenesis

Molecular functions

• DNA binding
• RNA polymerase II-specific DNA-binding transcription factor binding
• transcription coactivator activity
• transcription corepressor activity
• zinc ion binding

Cellular components

• chromatin
• cytoplasm
• male germ cell nucleus
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger C2H2-type
• Zinc finger CCHC FOG-type
• Zinc finger C2H2 superfamily
• FOG family
• Zinc finger protein ZFPM1/2, PR domain
• ZFPM2-like, C-terminal CCHC zinc finger
• Zinc finger protein ZFPM1-like, PR domain
• ZFPM2-like CCHC zinc finger

KeywordsUniProt

• Activator
• Cardiomyopathy
• Differentiation
• DNA-binding
• Gonadal differentiation
• Isopeptide bond
• Metal-binding
• Nucleus
• Phosphoprotein
• Repeat
• Repressor
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZFPM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATOH8
• GATA5
• NR2F2
• NR2F6
• GATA4