NR2F6
Nuclear receptor subfamily 2 group F member 6
Also known as: EAR-2, EAR2, ERBAL2, NR2F6_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P10588
- Gene
- NR2F6
- Ensembl
- ENSG00000160113
- Chromosome
- 19
- Canonical length
- 404 aa
- Protein class
- Nuclear receptors, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nuclear speckles,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
404 residues, UniProt reviewed canonical sequence.
>P10588|NR2F6
1 MAMVTGGWGG PGGDTNGVDK AGGYPRAAED DSASPPGAAS DAEPGDEERP GLQVDCVVCG
61 DKSSGKHYGV FTCEGCKSFF KRSIRRNLSY TCRSNRDCQI DQHHRNQCQY CRLKKCFRVG
121 MRKEAVQRGR IPHSLPGAVA ASSGSPPGSA LAAVASGGDL FPGQPVSELI AQLLRAEPYP
181 AAAGRFGAGG GAAGAVLGID NVCELAARLL FSTVEWARHA PFFPELPVAD QVALLRLSWS
241 ELFVLNAAQA ALPLHTAPLL AAAGLHAAPM AAERAVAFMD QVRAFQEQVD KLGRLQVDSA
301 EYGCLKAIAL FTPDACGLSD PAHVESLQEK AQVALTEYVR AQYPSQPQRF GRLLLRLPAL
361 RAVPASLISQ LFFMRLVGKT PIETLIRDML LSGSTFNWPY GSGQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NR2F6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 104 nTPM
Expression across tissuesHPA
Tissue
- liver: 104 nTPM
- esophagus: 46 nTPM
- pancreas: 43 nTPM
- colon: 37 nTPM
- stomach: 37 nTPM
- heart muscle: 37 nTPM
Single-cell type
- hepatocytes: 176 nCPM
- colonocytes: 154 nCPM
- esophageal apical cells: 147 nCPM
- foveolar cells: 137 nCPM
- respiratory secretory cells: 132 nCPM
- epididymal principal cells: 124 nCPM
Immune cell
- NK-cell: 4.7 nTPM
- naive CD4 T-cell: 3.8 nTPM
- T-reg: 2.4 nTPM
- memory CD4 T-cell: 2.3 nTPM
- naive B-cell: 2.3 nTPM
- gdT-cell: 1.7 nTPM
Brain region
- choroid plexus: 42 nTPM
- medulla oblongata: 42 nTPM
- cerebral cortex: 38 nTPM
- midbrain: 37 nTPM
- thalamus: 35 nTPM
- hypothalamus: 34 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.64
- gnomAD pLI
- 0.45
- gnomAD missense Z
- 1.87
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell differentiation
- detection of temperature stimulus involved in sensory perception of pain
- entrainment of circadian clock by photoperiod
- negative regulation of transcription by RNA polymerase II
- nervous system development
- neuron development
Molecular functions
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- nuclear receptor activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Nuclear hormone receptor, ligand-binding domain
- Zinc finger, nuclear hormone receptor-type
- Nuclear hormone receptor
- Zinc finger, NHR/GATA-type
- Nuclear hormone receptor-like domain superfamily
- Nuclear hormone receptor family NR2 subfamily
- Ligand-binding domain of nuclear hormone receptor
- Double treble clef zinc finger, C4 type
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NR2F6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NR2F6 as an antibody target. Whether an autoantibody or antibody against NR2F6 could matter depends on whether native NR2F6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NR2F6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NR2F6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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