Nuclear hormone receptor family NR2 subfamily
IPR050274
Definition
The nuclear hormone receptor family NR2 subfamily consists of transcription factors that play diverse roles in regulating gene expression in various biological processes, including development, metabolism, and immune response. Members of this family are characterized by their ability to bind DNA as monomers or heterodimers to hormone response elements (HREs) and modulate transcription in response to ligands such as retinoic acid. They are involved in critical functions such as retinal development, circadian rhythm maintenance, lipid metabolism, and embryogenesis. Some act as orphan receptors with no known ligands, while others are activated by retinoids. They can function as repressors or activators of transcription, influencing pathways like spermatogenesis, stem cell proliferation, and photoreceptor cell development. The family includes receptors that are essential for vision, regulators of hormonal responses, and mediators of developmental processes in both vertebrates and invertebrates.
12 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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