NICOL1
NELL2-interacting cell ontogeny regulator 1
Also known as: C4orf48, NICOL_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5BLP8
- Gene
- NICOL1
- Ensembl
- ENSG00000243449
- Chromosome
- 4
- Canonical length
- 95 aa
- Protein class
- Predicted secreted proteins
- Subcellular location
- Cytosol
- Secretome location
- Secreted to blood
OverviewNCBI Gene
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
95 residues, UniProt reviewed canonical sequence.
>Q5BLP8|NICOL1
1 MAPPPACRSP MSPPPPPLLL LLLSLALLGA RARAEPAGSA VPAQSRPCVD CHAFEFMQRA
61 LQDLRKTACS LDARTETLLL QAERRALCAC WPAGHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NICOL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 150 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 150 nTPM
- midbrain: 118 nTPM
- hypothalamus: 114 nTPM
- hippocampal formation: 111 nTPM
- amygdala: 100 nTPM
- basal ganglia: 87 nTPM
Single-cell type
- granulosa cells: 630 nCPM
- epididymal efferent duct ciliated cells: 600 nCPM
- late spermatids: 576 nCPM
- parietal cells: 553 nCPM
- melanocytes: 483 nCPM
- pancreatic islet cells: 404 nCPM
Immune cell
- classical monocyte: 465 nTPM
- eosinophil: 444 nTPM
- neutrophil: 361 nTPM
- intermediate monocyte: 334 nTPM
- plasmacytoid DC: 309 nTPM
- non-classical monocyte: 299 nTPM
Brain region
- white matter: 231 nTPM
- medulla oblongata: 200 nTPM
- cerebellum: 177 nTPM
- spinal cord: 172 nTPM
- basal ganglia: 169 nTPM
- midbrain: 164 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.32
- gnomAD pLI
- 0.51
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- NELL2-interacting cofactor for lumicrine signalling
- Neuropeptide-like
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NICOL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NICOL1 as an antibody target. Whether an autoantibody or antibody against NICOL1 could matter depends on whether native NICOL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NICOL1 is annotated as secreted, so native NICOL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label NICOL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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