NELL2-like, EGF domain
IPR024731
Definition
This entry represents an EGF domain found in several proteins, including NELL2, Cubilin, Uromodulin, Fibrillin and related proteins that contain EGF repeats. Some of these proteins have calcium-binding properties. NELL2 is almost exclusively expressed in the nervous system. In the mammalian brain, NELL2 expression is mostly neuronal. NELL2 was previously found to be a secreted protein that functions during embryonic development as a neuronal differentiation and survival factor PMID:18547942. NELL2 is a component of glutamatergic neurons and provide evidence for its physiological involvement in a major, glutamate-dependent, process of neuroendocrine regulation.
17 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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