Thrombospondin-like, N-terminal domain
IPR048287
Definition
This entry represents the heparin-binding and cell adhesion domain of thrombospondin and related proteins such as protein kinase C-binding protein NELL1 and NELL2, and collagen alpha. Thrombospondins (TSPs) are secreted, calcium-binding glycoproteins that play an essential role in regulating cell-cell and cell-matrix interactions. They are divided into trimeric subgroup A (TSP-1 and TSP-2) and pentameric subgroup B (TSP-3-5). The actions of TSPs depend on their binding partners in a given environment. The N-terminal domain of TSPs plays an integral role in the interaction of TSPs with other secreted and transmembrane proteins, and proteoglycans. This domain folds into a β-sandwich typical for concanavalin A-like lectins/glucanases superfamily ([pdbe:1Z78]) [[cite:PMID:16407063], [cite:PMID:18065761]].
23 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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