Seroatlas · Human Serome Atlas

LIN54

Protein lin-54 homolog

Also known as: CXCDC1, DKFZp686L1814, JC8.6, LIN54_HUMAN, MIP120, TCX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6MZP7
Gene: LIN54
Ensembl: ENSG00000189308
Chromosome: 4
Canonical length: 749 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]

Canonical amino-acid sequenceUniProt

749 residues, UniProt reviewed canonical sequence.

>Q6MZP7|LIN54
     1  MEVVPAEVNS LLPEEIMDTG ITLVDDDSIE AVIVSSPIPM ETELEEIVNI NSTGDSTATP
    61  ISTEPITVYS NHTNQVAVNT TITKADSNTT VKPAFPSGLQ KLGAQTPVTI SANQIILNKV
   121  SQTSDLKLGN QTLKPDGQKL ILTTLGKSGS PIVLALPHSQ LPQAQKVTTQ AQSGDAKLPP
   181  QQIKVVTIGG RPEVKPVIGV SALTPGSQLI NTTTQPSVLQ TQQLKTVQIA KKPRTPTSGP
   241  VITKLIFAKP INSKAVTGQT TQVSPPVIAG RVLSQSTPGT PSKTITISES GVIGSTLNST
   301  TQTPNKIAIS PLKSPNKAVK STVQTITVGG VSTSQFKTII PLATAPNVQQ IQVPGSKFHY
   361  VRLVTATSAS SSTQPVSQNP STNTQPLQQA KPVVVNTTPV RMSVPIVSAQ AVKQVVPKPI
   421  NPTSQIVTTS QPQQRLIMPA TPLPQIQPNL TNLPPGTVLA PAPGTGNVGY AVLPAQYVTQ
   481  LQQSSYVSIA SNSTFTGTSG IQTQARLPFN GIIPSESASR PRKPCNCTKS LCLKLYCDCF
   541  ANGEFCNNCN CTNCYNNLEH ENERQKAIKA CLDRNPEAFK PKIGKGKEGE SDRRHSKGCN
   601  CKRSGCLKNY CECYEAKIMC SSICKCIGCK NFEESPERKT LMHLADAAEV RVQQQTAAKT
   661  KLSSQISDLL TRPTPALNSG GGKLPFTFVT KEVAEATCNC LLAQAEQADK KGKSKAAAER
   721  MILEEFGRCL MSVINSAGKA KSDPCAMNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIN54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 12 nTPM
thymus: 12 nTPM
esophagus: 9.9 nTPM
thyroid gland: 9.6 nTPM
retina: 9.3 nTPM
tonsil: 8.1 nTPM

Single-cell type

neutrophils: 195 nCPM
neutrophil progenitors: 191 nCPM
monocyte progenitors: 132 nCPM
esophageal apical cells: 122 nCPM
erythrocyte progenitors: 80 nCPM
myonuclei: 70 nCPM

Immune cell

non-classical monocyte: 6.6 nTPM
eosinophil: 5.5 nTPM
neutrophil: 5.4 nTPM
T-reg: 4.7 nTPM
naive CD4 T-cell: 4.6 nTPM
NK-cell: 4.6 nTPM

Brain region

white matter: 22 nTPM
cerebellum: 18 nTPM
medulla oblongata: 17 nTPM
basal ganglia: 16 nTPM
pons: 16 nTPM
spinal cord: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 2.7
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIN54 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIN54 as an antibody target. Whether an autoantibody or antibody against LIN54 could matter depends on whether native LIN54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIN54 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIN54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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