Seroatlas · Human Serome Atlas

ZNF622

Cytoplasmic 60S subunit biogenesis factor ZNF622

Also known as: MGC17552, MGC2485, ZN622_HUMAN, ZPR9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969S3
Gene: ZNF622
Ensembl: ENSG00000173545
Chromosome: 5
Canonical length: 477 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables preribosome binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Located in Golgi apparatus; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q969S3|ZNF622
     1  MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER VRAQRAVAEE
    61  ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ AVNRKVEMMN EKNLEKGLGV
   121  DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA PAKEARNVVA VGTGGRGTHD RDPSEKPPRL
   181  QWFEQQAKKL AKQQEEDSEE EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA
   241  EEGPPLGAIP ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG
   301  VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR SSYPDHKEGE
   361  DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY KQRFGLSRAV AVAKNRKAVG
   421  RVLQQYRALG WTGSTGAALM RERDMQYVQR MKSKWMLKTG MKNNATKQMH FRVQVRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF622 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 53 nTPM
pancreas: 52 nTPM
skeletal muscle: 40 nTPM
bone marrow: 34 nTPM
skin: 24 nTPM
tongue: 24 nTPM

Single-cell type

early spermatids: 148 nCPM
endometrial glandular cells: 99 nCPM
enterocytes: 97 nCPM
late spermatids: 96 nCPM
cytotrophoblasts: 77 nCPM
extravillous trophoblasts: 77 nCPM

Immune cell

basophil: 89 nTPM
eosinophil: 89 nTPM
neutrophil: 88 nTPM
memory B-cell: 86 nTPM
T-reg: 85 nTPM
naive CD4 T-cell: 84 nTPM

Brain region

white matter: 30 nTPM
cerebral cortex: 30 nTPM
basal ganglia: 29 nTPM
midbrain: 28 nTPM
pons: 27 nTPM
amygdala: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.11
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF622 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF622 as an antibody target. Whether an autoantibody or antibody against ZNF622 could matter depends on whether native ZNF622 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF622 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF622 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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