Seroatlas · Human Serome Atlas

LIN9

Protein lin-9 homolog

Also known as: LIN9_HUMAN, TGS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TKA1
Gene: LIN9
Ensembl: ENSG00000183814
Chromosome: 1
Canonical length: 542 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q5TKA1|LIN9
     1  MAELDQLPDE SSSAKALVSL KEGSLSNTWN EKYSSLQKTP VWKGRNTSSA VEMPFRNSKR
    61  SRLFSDEDDR QINTRSPKRN QRVAMVPQKF TATMSTPDKK ASQKIGFRLR NLLKLPKAHK
   121  WCIYEWFYSN IDKPLFEGDN DFCVCLKESF PNLKTRKLTR VEWGKIRRLM GKPRRCSSAF
   181  FEEERSALKQ KRQKIRLLQQ RKVADVSQFK DLPDEIPLPL VIGTKVTARL RGVHDGLFTG
   241  QIDAVDTLNA TYRVTFDRTG LGTHTIPDYE VLSNEPHETM PIAAFGQKQR PSRFFMTPPR
   301  LHYTPPLQSP IIDNDPLLGQ SPWRSKISGS DTETLGGFPV EFLIQVTRLS KILMIKKEHI
   361  KKLREMNTEA EKLKSYSMPI SIEFQRRYAT IVLELEQLNK DLNKVLHKVQ QYCYELAPDQ
   421  GLQPADQPTD MRRRCEEEAQ EIVRHANSST GQPCVENENL TDLISRLTAI LLQIKCLAEG
   481  GDLNSFEFKS LTDSLNDIKS TIDASNISCF QNNVEIHVAH IQSGLSQMGN LHAFAANNTN
   541  RD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIN9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 12 nTPM
testis: 9.1 nTPM
thymus: 7.6 nTPM
bone marrow: 6.2 nTPM
ovary: 4.8 nTPM
lymph node: 4.6 nTPM

Single-cell type

cardiomyocytes: 92 nCPM
early primary spermatocytes: 72 nCPM
erythrocyte progenitors: 66 nCPM
undifferentiated spermatogonia: 49 nCPM
differentiating spermatogonia: 48 nCPM
monocyte progenitors: 46 nCPM

Immune cell

basophil: 4.1 nTPM
naive CD4 T-cell: 3.4 nTPM
non-classical monocyte: 2.8 nTPM
T-reg: 2.8 nTPM
memory CD8 T-cell: 2.7 nTPM
naive CD8 T-cell: 2.6 nTPM

Brain region

cerebellum: 8.2 nTPM
cerebral cortex: 4 nTPM
white matter: 3.3 nTPM
basal ganglia: 3 nTPM
midbrain: 2.8 nTPM
amygdala: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 2.39
DepMap mean gene effect: -0.53
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein LIN-9/Protein ALWAYS EARLY
DIRP domain
LIN-9, C-terminal
DIRP
LIN9 C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIN9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIN9 as an antibody target. Whether an autoantibody or antibody against LIN9 could matter depends on whether native LIN9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIN9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIN9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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