Paraneoplastic antigen Ma-like, C-terminal domain
IPR048270
Definition
This entry represents a domain found towards the C-terminal of paraneoplastic Ma antigens (PNMAs) and similar proteins. This domain is found at the N-terminal of Zinc finger CCHC domain-containing protein 12. The paraneoplastic Ma antigens (PNMA) have been identified using sera from patients with paraneoplastic neurological syndromes PMID:16214224. This entry includes paraneoplastic antigen PNMA1 PMID:10050892, PNMA2 PMID:10362822, PNMA3 PMID:11558790, PNMA4 (also known as modulator of apoptosis 1 or MOAP-1) PMID:11060313 and some paraneoplastic antigen-like proteins (PNMA5 and PNMA6). PNMA4/MOAP-1 has a role in death receptor-dependent apoptosis PMID:15949439, and it also plays a role in autophagy as it promotes phagophore closure via association with ATG8 proteins PMID:33783314. Zinc finger CCHC domain-containing protein 12 (ZCCHC12, also known as Sizn1 in mouse), also a member of this entry, is a transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression PMID:18160706. This protein may be a potential molecular marker of papillary thyroid carcinoma PMID:21739307.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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