Seroatlas · Human Serome Atlas

MEAK7

MTOR-associated protein MEAK7

Also known as: KIAA1609, mEAK-7, MEAK7_HUMAN, TLDC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P9B6
Gene
MEAK7
Ensembl
ENSG00000140950
Chromosome
16
Canonical length
456 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Involved in several processes, including TOR signaling; positive regulation of protein localization to lysosome; and response to insulin. Located in cytosol; lysosomal membrane; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q6P9B6|MEAK7
     1  MGNSRSRVGR SFCSQFLPEE QAEIDQLFDA LSSDKNSPNV SSKSFSLKAL QNHVGEALPP
    61  EMVTRLYDGM RRVDLTGKAK GPSENVSQEQ FTASMSHLLK GNSEEKSLMI MKMISATEGP
   121  VKAREVQKFT EDLVGSVVHV LSHRQELRGW TGKEAPGPNP RVQVLAAQLL SDMKLQDGKR
   181  LLGPQWLDYD CDRAVIEDWV FRVPHVAIFL SVVICKGFLI LCSSLDLTTL VPERQVDQGR
   241  GFESILDVLS VMYINAQLPR EQRHRWCLLF SSELHGHSFS QLCGHITHRG PCVAVLEDHD
   301  KHVFGGFASC SWEVKPQFQG DNRCFLFSIC PSMAVYTHTG YNDHYMYLNH GQQTIPNGLG
   361  MGGQHNYFGL WVDVDFGKGH SRAKPTCTTY NSPQLSAQEN FQFDKMEVWA VGDPSEEQLA
   421  KGNKSILDAD PEAQALLEIS GHSRHSEGLR EVPDDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEAK7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 12 nTPM
  • placenta: 10 nTPM
  • skin: 7.2 nTPM
  • parathyroid gland: 6.9 nTPM
  • urinary bladder: 6.8 nTPM
  • cervix: 6.3 nTPM

Single-cell type

  • cone photoreceptor cells: 149 nCPM
  • rod photoreceptor cells: 96 nCPM
  • esophageal suprabasal cells: 77 nCPM
  • syncytiotrophoblasts: 75 nCPM
  • esophageal apical cells: 65 nCPM
  • cytotrophoblasts: 61 nCPM

Immune cell

  • basophil: 17 nTPM
  • T-reg: 7.9 nTPM
  • naive CD4 T-cell: 6.1 nTPM
  • memory CD4 T-cell: 5.6 nTPM
  • memory CD8 T-cell: 4.6 nTPM
  • eosinophil: 3.9 nTPM

Brain region

  • pons: 18 nTPM
  • choroid plexus: 18 nTPM
  • hippocampal formation: 17 nTPM
  • amygdala: 16 nTPM
  • basal ganglia: 16 nTPM
  • white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEAK7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEAK7 as an antibody target. Whether an autoantibody or antibody against MEAK7 could matter depends on whether native MEAK7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEAK7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEAK7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MEAK7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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