Seroatlas · Human Serome Atlas

MAPK10

Mitogen-activated protein kinase 10

Also known as: JNK3, MK10_HUMAN, p493F12, p54bSAPK, PRKM10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53779
Gene
MAPK10
Ensembl
ENSG00000109339
Chromosome
4
Canonical length
464 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>P53779|MAPK10
     1  MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV
    61  LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH
   121  KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL
   181  HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY
   241  KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN
   301  RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN
   361  VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA
   421  VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPK10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 74 nTPM
  • midbrain: 47 nTPM
  • amygdala: 44 nTPM
  • hippocampal formation: 41 nTPM
  • hypothalamus: 39 nTPM
  • basal ganglia: 39 nTPM

Single-cell type

  • ependymal cells: 2,327 nCPM
  • choroid plexus epithelial cells: 2,097 nCPM
  • respiratory ciliated cells: 1,789 nCPM
  • astrocytes: 1,652 nCPM
  • bergmann glia: 1,620 nCPM
  • thyrotrophs: 1,412 nCPM

Immune cell

  • neutrophil: 4.4 nTPM
  • basophil: 3.1 nTPM
  • naive CD8 T-cell: 1.4 nTPM
  • memory B-cell: 1.3 nTPM
  • eosinophil: 1.2 nTPM
  • naive B-cell: 1.2 nTPM

Brain region

  • cerebral cortex: 289 nTPM
  • hippocampal formation: 219 nTPM
  • white matter: 212 nTPM
  • basal ganglia: 209 nTPM
  • thalamus: 185 nTPM
  • midbrain: 180 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.28
gnomAD missense Z
3.04
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPK10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPK10 as an antibody target. Whether an autoantibody or antibody against MAPK10 could matter depends on whether native MAPK10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPK10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAPK10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAPK10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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