Seroatlas · Human Serome Atlas

SH3BP5

SH3 domain-binding protein 5

Also known as: 3BP5_HUMAN, Sab

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60239
Gene: SH3BP5
Ensembl: ENSG00000131370
Chromosome: 3
Canonical length: 455 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Acts upstream of or within intracellular signal transduction. Located in cytoplasmic vesicle membrane and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

455 residues, UniProt reviewed canonical sequence.

>O60239|SH3BP5
     1  MDAALKRSRS EEPAEILPPA RDEEEEEEEG MEQGLEEEEE VDPRIQGELE KLNQSTDDIN
    61  RRETELEDAR QKFRSVLVEA TVKLDELVKK IGKAVEDSKP YWEARRVARQ AQLEAQKATQ
   121  DFQRATEVLR AAKETISLAE QRLLEDDKRQ FDSAWQEMLN HATQRVMEAE QTKTRSELVH
   181  KETAARYNAA MGRMRQLEKK LKRAINKSKP YFELKAKYYV QLEQLKKTVD DLQAKLTLAK
   241  GEYKMALKNL EMISDEIHER RRSSAMGPRG CGVGAEGSST SVEDLPGSKP EPDAISVASE
   301  AFEDDSCSNF VSEDDSETQS VSSFSSGPTS PSEMPDQFPA VVRPGSLDLP SPVSLSEFGM
   361  MFPVLGPRSE CSGASSPECE VERGDRAEGA ENKTSDKANN NRGLSSSSGS GGSSKSQSST
   421  SPEGQALENR MKQLSLQCSK GRDGIIADIK MVQIG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3BP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 146 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 146 nTPM
ovary: 90 nTPM
bone marrow: 69 nTPM
adipose tissue: 68 nTPM
fallopian tube: 67 nTPM
skeletal muscle: 63 nTPM

Single-cell type

adrenal cortex cells: 806 nCPM
neutrophils: 795 nCPM
extravillous trophoblasts: 619 nCPM
monocytes: 352 nCPM
early spermatids: 303 nCPM
syncytiotrophoblasts: 299 nCPM

Immune cell

gdT-cell: 53 nTPM
memory CD8 T-cell: 36 nTPM
NK-cell: 26 nTPM
naive B-cell: 24 nTPM
memory CD4 T-cell: 24 nTPM
total PBMC: 20 nTPM

Brain region

cerebellum: 94 nTPM
white matter: 86 nTPM
cerebral cortex: 65 nTPM
hippocampal formation: 62 nTPM
pons: 62 nTPM
medulla oblongata: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.05
gnomAD missense Z: 0.96
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH3BP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3BP5 as an antibody target. Whether an autoantibody or antibody against SH3BP5 could matter depends on whether native SH3BP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3BP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH3BP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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