Seroatlas · Human Serome Atlas

LUZP1

Leucine zipper protein 1

Also known as: LUZP, LUZP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86V48
Gene
LUZP1
Ensembl
ENSG00000169641
Chromosome
1
Canonical length
1076 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Vesicles,Actin filaments,Cytokinetic bridge,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a protein that contains a leucine zipper motif. The exact function of the encoded protein is not known. In mice this gene affects neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

1076 residues, UniProt reviewed canonical sequence.

>Q86V48|LUZP1
     1  MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK VIQAEGSNSS
    61  MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE NLTRELKSEI ERLQKRMAEL
   121  EKLEEAFSRS KNDCTQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLA
   181  SELEKLKSLT LSFVSERKYL NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL
   241  RIEDGISSTL PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT
   301  QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ KELENGEVEG
   361  EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE RLRNREFALN NENYSLSNRQ
   421  VSSPSFTNRR AAKASHMGVS TDSGTQETKK TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA
   481  AQEHSKAWKG TSKPGTESGL KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG
   541  KRGHVLGNGS QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP
   601  VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK SSGREKPDSD
   661  DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP RTSLFENDKD AGMENESVKS
   721  VRASTNTMEL PDTNGAGVKS QRPFSPREAL RSRAIIKPVI VDKDVKKIMG GSGTETTLEK
   781  QKPVSKPGPN KVTSSITIYP SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS
   841  PFELSIHKHD ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR
   901  WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN AYTQRSSTDF
   961  SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS EVLTRRNRVG DTITVAAWNH
  1021  SASMEEEGED CTLSVYRQLH NSLDPSELPG KQGLPESGRV RAEERLRPTR PCAEEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LUZP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 23 nTPM
  • duodenum: 21 nTPM
  • parathyroid gland: 19 nTPM
  • adrenal gland: 13 nTPM
  • bone marrow: 13 nTPM
  • heart muscle: 13 nTPM

Single-cell type

  • early spermatids: 366 nCPM
  • ocular epithelial cells: 274 nCPM
  • urothelial cells: 234 nCPM
  • vascular endothelial cells: 220 nCPM
  • endometrial stromal cells: 210 nCPM
  • basal keratinocytes: 194 nCPM

Immune cell

  • basophil: 40 nTPM
  • plasmacytoid DC: 16 nTPM
  • MAIT T-cell: 13 nTPM
  • gdT-cell: 12 nTPM
  • non-classical monocyte: 11 nTPM
  • memory CD4 T-cell: 8.6 nTPM

Brain region

  • cerebral cortex: 74 nTPM
  • pons: 52 nTPM
  • thalamus: 49 nTPM
  • hypothalamus: 46 nTPM
  • white matter: 46 nTPM
  • medulla oblongata: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.53
gnomAD missense Z
0.72
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LUZP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LUZP1 as an antibody target. Whether an autoantibody or antibody against LUZP1 could matter depends on whether native LUZP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LUZP1 is annotated at the cell surface, where native LUZP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LUZP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LUZP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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