Seroatlas · Human Serome Atlas

NPTXR

Neuronal pentraxin receptor

Also known as: NPTXR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95502
Gene
NPTXR
Ensembl
ENSG00000221890
Chromosome
22
Canonical length
500 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>O95502|NPTXR
     1  MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGA DNASVASGAA ASPGPQRSLS
    61  ALHGAGGSAG PPALPGAPAA SAHPLPPGPL FSRFLCTPLA AACPSGAQQG DAAGAAPGER
   121  EELLLLQSTA EQLRQTALQQ EARIRADQDT IRELTGKLGR CESGLPRGLQ GAGPRRDTMA
   181  DGPWDSPALI LELEDAVRAL RDRIDRLEQE LPARVNLSAA PAPVSAVPTG LHSKMDQLEG
   241  QLLAQVLALE KERVALSHSS RRQRQEVEKE LDVLQGRVAE LEHGSSAYSP PDAFKISIPI
   301  RNNYMYARVR KALPELYAFT ACMWLRSRSS GTGQGTPFSY SVPGQANEIV LLEAGHEPME
   361  LLINDKVAQL PLSLKDNGWH HICIAWTTRD GLWSAYQDGE LQGSGENLAA WHPIKPHGIL
   421  ILGQEQDTLG GRFDATQAFV GDIAQFNLWD HALTPAQVLG IANCTAPLLG NVLPWEDKLV
   481  EAFGGATKAA FDVCKGRAKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPTXR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
179 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 179 nTPM
  • cerebral cortex: 131 nTPM
  • amygdala: 111 nTPM
  • cerebellum: 47 nTPM
  • hypothalamus: 42 nTPM
  • blood vessel: 21 nTPM

Single-cell type

  • brain excitatory neurons: 101 nCPM
  • brain inhibitory neurons: 51 nCPM
  • other brain neurons: 40 nCPM
  • oligodendrocyte progenitor cells: 30 nCPM
  • retinal amacrine cells: 26 nCPM
  • endometrial secretory cells: 21 nCPM

Immune cell

  • memory CD8 T-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • MAIT T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • basophil: 0.1 nTPM

Brain region

  • hippocampal formation: 654 nTPM
  • cerebral cortex: 366 nTPM
  • amygdala: 254 nTPM
  • basal ganglia: 218 nTPM
  • thalamus: 186 nTPM
  • white matter: 160 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.72
gnomAD missense Z
1.26
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NPTXR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPTXR as an antibody target. Whether an autoantibody or antibody against NPTXR could matter depends on whether native NPTXR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPTXR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPTXR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPTXR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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