Seroatlas · Human Serome Atlas

KPNA5

Importin subunit alpha-6

Also known as: IMA6_HUMAN, IPOA6, SRP6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15131
Gene
KPNA5
Ensembl
ENSG00000196911
Chromosome
6
Canonical length
539 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

539 residues, UniProt reviewed canonical sequence.

>O15131|KPNA5
     1  MDAMASPGKD NYRMKSYKNK ALNPQEMRRR REEEGIQLRK QKREEQLFKR RNVYLPRNDE
    61  SMLESPIQDP DISSTVPIPE EEVVTTDMVQ MIFSNNADQQ LTATQKFRKL LSKEPNPPID
   121  QVIQKPGVVQ RFVKFLERNE NCTLQFEAAW ALTNIASGTF LHTKVVIETG AVPIFIKLLN
   181  SEHEDVQEQA VWALGNIAGD NAECRDFVLN CEILPPLLEL LTNSNRLTTT RNAVWALSNL
   241  CRGKNPPPNF SKVSPCLNVL SRLLFSSDPD VLADVCWALS YLSDGPNDKI QAVIDSGVCR
   301  RLVELLMHND YKVVSPALRA VGNIVTGDDI QTQVILNCSA LPCLLHLLSS PKESIRKEAC
   361  WTVSNITAGN RAQIQAVIDA NIFPVLIEIL QKAEFRTRKE AAWAITNATS GGTPEQIRYL
   421  VALGCIKPLC DLLTVMDSKI VQVALNGLEN ILRLGEQESK QNGIGINPYC ALIEEAYGLD
   481  KIEFLQSHEN QEIYQKAFDL IEHYFGVEED DPSIVPQVDE NQQQFIFQQQ EAPMDGFQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KPNA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • testis: 39 nTPM
  • retina: 19 nTPM
  • ovary: 16 nTPM
  • skeletal muscle: 12 nTPM
  • tongue: 12 nTPM
  • thyroid gland: 11 nTPM

Single-cell type

  • late primary spermatocytes: 387 nCPM
  • lactotrophs: 124 nCPM
  • pericytes: 123 nCPM
  • gonadotrophs: 121 nCPM
  • thyrotrophs: 120 nCPM
  • adrenal medulla cells: 117 nCPM

Immune cell

  • naive CD4 T-cell: 7.7 nTPM
  • basophil: 5.8 nTPM
  • naive CD8 T-cell: 5.1 nTPM
  • NK-cell: 4.7 nTPM
  • memory CD8 T-cell: 4.6 nTPM
  • naive B-cell: 4.5 nTPM

Brain region

  • cerebellum: 41 nTPM
  • cerebral cortex: 35 nTPM
  • white matter: 34 nTPM
  • pons: 32 nTPM
  • medulla oblongata: 29 nTPM
  • basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
gnomAD missense Z
1.26
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KPNA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KPNA5 as an antibody target. Whether an autoantibody or antibody against KPNA5 could matter depends on whether native KPNA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KPNA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KPNA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KPNA5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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