Seroatlas · Human Serome Atlas

KATNBL1

KATNB1-like protein 1

Also known as: C15orf29, FLJ22557, KTBL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H079
Gene: KATNBL1
Ensembl: ENSG00000134152
Chromosome: 15
Canonical length: 304 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody,Cleavage furrow,Mitotic spindle

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Involved in cytoplasmic microtubule organization and positive regulation of cytoskeleton organization. Located in several cellular components, including cleavage furrow; mitotic spindle pole; and nuclear lumen. Part of katanin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q9H079|KATNBL1
     1  MASETHNVKK RNFCNKIEDH FIDLPRKKIS NFTNKNMKEV KKSPKQLAAY INRTVGQTVK
    61  SPDKLRKVIY RRKKVHHPFP NPCYRKKQSP GSGGCDMANK ENELACAGHL PEKLHHDSRT
   121  YLVNSSDSGS SQTESPSSKY SGFFSEVSQD HETMAQVLFS RNMRLNVALT FWRKRSISEL
   181  VAYLLRIEDL GVVVDCLPVL TNCLQEEKQY ISLGCCVDLL PLVKSLLKSK FEEYVIVGLN
   241  WLQAVIKRWW SELSSKTEII NDGNIQILKQ QLSGLWEQEN HLTLVPGYTG NIAKDVDAYL
   301  LQLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KATNBL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

esophagus: 38 nTPM
placenta: 30 nTPM
skin: 29 nTPM
retina: 29 nTPM
vagina: 27 nTPM
smooth muscle: 24 nTPM

Single-cell type

esophageal apical cells: 1,326 nCPM
neutrophils: 1,075 nCPM
syncytiotrophoblasts: 424 nCPM
sertoli cells: 318 nCPM
bergmann glia: 202 nCPM
myonuclei: 179 nCPM

Immune cell

neutrophil: 128 nTPM
basophil: 62 nTPM
eosinophil: 30 nTPM
plasmacytoid DC: 29 nTPM
naive B-cell: 26 nTPM
memory B-cell: 24 nTPM

Brain region

cerebellum: 78 nTPM
choroid plexus: 73 nTPM
white matter: 69 nTPM
cerebral cortex: 64 nTPM
thalamus: 59 nTPM
amygdala: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.73
gnomAD missense Z: 0.73
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KATNBL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KATNBL1 as an antibody target. Whether an autoantibody or antibody against KATNBL1 could matter depends on whether native KATNBL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KATNBL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KATNBL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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