CEBPD

Protein identityUniProt · HPA

UniProt accession

P49716

Gene

CEBPD

Ensembl

ENSG00000221869

Chromosome

8

Canonical length

269 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

269 residues, UniProt reviewed canonical sequence.

>P49716|CEBPD
     1  MSAALFSLDG PARGAPWPAE PAPFYEPGRA GKPGRGAEPG ALGEPGAAAP AMYDDESAID
    61  FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAGGAGPLEL LPGGPARPLG PGPAAPRLLK
   121  REPDWGDGDA PGSLLPAQVA ACAQTVVSLA AAGQPTPPTS PEPPRSSPRQ TPAPGPAREK
   181  SAGKRGPDRG SPEYRQRRER NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL
   241  TRDLAGLRQF FKQLPSPPFL PAAGTADCR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEBPD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.65

Highest tissue expression

475 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.98

gnomAD pLI

0.61

gnomAD missense Z

0.32

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fat cell differentiation
• hematopoietic progenitor cell differentiation
• inner ear development
• integrated stress response signaling
• negative regulation of DNA-templated transcription
• positive regulation of osteoblast differentiation
• regulation of cell differentiation
• regulation of transcription by RNA polymerase II
• transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• identical protein binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleoplasm
• nucleus
• RNA polymerase II transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• Basic-leucine zipper domain
• CCAAT/enhancer-binding protein, chordates
• CCAAT/enhancer-binding protein C/EBP
• Basic-leucine zipper domain superfamily
• Basic region leucine zipper

KeywordsUniProt

• Acetylation
• Activator
• DNA-binding
• Isopeptide bond
• Nucleus
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of CEBPD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRDM16
• ZNF638
• FANCD2
• IPO4