IGFBP2

Protein identityUniProt · HPA

UniProt accession

P18065

Gene

IGFBP2

Ensembl

ENSG00000115457

Chromosome

2

Canonical length

325 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Endoplasmic reticulum

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>P18065|IGFBP2
     1  MLPRVGCPAL PLPPPPLLPL LLLLLGASGG GGGARAEVLF RCPPCTPERL AACGPPPVAP
    61  PAAVAAVAGG ARMPCAELVR EPGCGCCSVC ARLEGEACGV YTPRCGQGLR CYPHPGSELP
   121  LQALVMGEGT CEKRRDAEYG ASPEQVADNG DDHSEGGLVE NHVDSTMNML GGGGSAGRKP
   181  LKSGMKELAV FREKVTEQHR QMGKGGKHHL GLEEPKKLRP PPARTPCQQE LDQVLERIST
   241  MRLPDERGPL EHLYSLHIPN CDKHGLYNLK QCKMSLNGQR GECWCVNPNT GKLIQGAPTI
   301  RGDPECHLFY NEQQEARGVH TQRMQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGFBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

1,281 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGFBP2.

Disease | ImmuneIEDB

Conditions an epitope on IGFBP2 was assayed in.

• breast cancer T cell

ReferencesPubMed · IEDB

Publications for IGFBP2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.82

gnomAD pLI

0.12

gnomAD missense Z

1.71

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to hormone stimulus
• female pregnancy
• negative regulation of canonical Wnt signaling pathway
• osteoblast differentiation
• positive regulation of activated T cell proliferation
• regulation of insulin-like growth factor receptor signaling pathway
• response to estradiol
• response to estrogen
• response to glucocorticoid
• response to mechanical stimulus
• response to nutrient
• response to retinoic acid
• response to xenobiotic stimulus

Molecular functions

• insulin-like growth factor I binding
• insulin-like growth factor II binding
• receptor ligand inhibitor activity
• signaling receptor binding

Cellular components

• apical plasma membrane
• extracellular exosome
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Thyroglobulin type-1
• Insulin-like growth factor-binding protein, IGFBP
• Growth factor receptor cysteine-rich domain superfamily
• Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
• Insulin-like growth factor-binding protein family 1-6, chordata
• Thyroglobulin type-1 superfamily
• Thyroglobulin type-1 repeat
• Insulin-like growth factor binding protein
• Insulin-like growth factor binding protein 2

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Growth factor binding
• Growth regulation
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IGFBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IGF1
• IGF2
• PTPRB
• ITGA5
• MIIP
• INO80B