Seroatlas · Human Serome Atlas

CYTH1

Cytohesin-1

Also known as: B2-1, CYH1_HUMAN, cytohesin-1, D17S811E, PSCD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15438
Gene: CYTH1
Ensembl: ENSG00000108669
Chromosome: 17
Canonical length: 398 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q15438|CYTH1
     1  MEEDDSYVPS DLTAEERQEL ENIRRRKQEL LADIQRLKDE IAEVANEIEN LGSTEERKNM
    61  QRNKQVAMGR KKFNMDPKKG IQFLIENDLL KNTCEDIAQF LYKGEGLNKT AIGDYLGERD
   121  EFNIQVLHAF VELHEFTDLN LVQALRQFLW SFRLPGEAQK IDRMMEAFAQ RYCQCNNGVF
   181  QSTDTCYVLS FAIIMLNTSL HNPNVKDKPT VERFIAMNRG INDGGDLPEE LLRNLYESIK
   241  NEPFKIPEDD GNDLTHTFFN PDREGWLLKL GGGRVKTWKR RWFILTDNCL YYFEYTTDKE
   301  PRGIIPLENL SIREVEDSKK PNCFELYIPD NKDQVIKACK TEADGRVVEG NHTVYRISAP
   361  TPEEKEEWIK CIKAAISRDP FYEMLAARKK KVSSTKRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYTH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

retina: 73 nTPM
spinal cord: 60 nTPM
bone marrow: 55 nTPM
lymph node: 55 nTPM
spleen: 54 nTPM
tonsil: 53 nTPM

Single-cell type

neutrophils: 872 nCPM
monocytes: 698 nCPM
cone photoreceptor cells: 557 nCPM
endometrial glandular cells: 503 nCPM
t-cells: 500 nCPM
cdc: 450 nCPM

Immune cell

basophil: 133 nTPM
total PBMC: 89 nTPM
gdT-cell: 88 nTPM
eosinophil: 80 nTPM
naive CD4 T-cell: 79 nTPM
neutrophil: 77 nTPM

Brain region

white matter: 92 nTPM
basal ganglia: 68 nTPM
medulla oblongata: 66 nTPM
midbrain: 66 nTPM
pons: 64 nTPM
thalamus: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 2.44
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CYTH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYTH1 as an antibody target. Whether an autoantibody or antibody against CYTH1 could matter depends on whether native CYTH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYTH1 is annotated at the cell surface, where native CYTH1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CYTH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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