Seroatlas · Human Serome Atlas

CCDC181

Coiled-coil domain-containing protein 181

Also known as: C1orf114, CC181_HUMAN, FLJ25846

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TID7
Gene: CCDC181
Ensembl: ENSG00000117477
Chromosome: 1
Canonical length: 509 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Acrosome,Mid piece,Principal piece
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Predicted to be located in manchette and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

509 residues, UniProt reviewed canonical sequence.

>Q5TID7|CCDC181
     1  MNENKDTDSK KSEEYEDDFE KDLEWLINEN EKSDASIIEM ACEKEENINQ DLKENETVME
    61  HTKRHSDPDK SLQDEVSPRR NDIISVPGIQ PLDPISDSDS ENSFQESKLE SQKDLEEEED
   121  EEVRRYIMEK IVQANKLLQN QEPVNDKRER KLKFKDQLVD LEVPPLEDTT TFKNYFENER
   181  NMFGKLSQLC ISNDFGQEDV LLSLTNGSCE ENKDRTILVE RDGKFELLNL QDIASQGFLP
   241  PINNANSTEN DPQQLLPRSS NSSVSGTKKE DSTAKIHAVT HSSTGEPLAY IAQPPLNRKT
   301  CPSSAVNSDR SKGNGKSNHR TQSAHISPVT STYCLSPRQK ELQKQLEEKR EKLKREEERR
   361  KIEEEKEKKR ENDIVFKAWL QKKREQVLEM RRIQRAKEIE DMNSRQENRD PQQAFRLWLK
   421  KKHEEQMKER QTEELRKQEE CLFFLKGTEG RERAFKQWLR RKRMEKMAEQ QAVRERTRQL
   481  RLEAKRSKQL QHHLYMSEAK PFRFTDHYN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC181 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

retina: 37 nTPM
choroid plexus: 31 nTPM
testis: 25 nTPM
pituitary gland: 17 nTPM
fallopian tube: 11 nTPM
parathyroid gland: 11 nTPM

Single-cell type

late primary spermatocytes: 380 nCPM
early spermatids: 264 nCPM
respiratory ciliated cells: 173 nCPM
fallopian tube ciliated cells: 166 nCPM
early primary spermatocytes: 122 nCPM
epididymal efferent duct ciliated cells: 121 nCPM

Immune cell

basophil: 1 nTPM
eosinophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 20 nTPM
hypothalamus: 13 nTPM
midbrain: 12 nTPM
cerebellum: 9.9 nTPM
cerebral cortex: 9.3 nTPM
medulla oblongata: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 181

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC181 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC181 as an antibody target. Whether an autoantibody or antibody against CCDC181 could matter depends on whether native CCDC181 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC181 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC181 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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