MSR1

Protein identityUniProt · HPA

UniProt accession

P21757

Gene

MSR1

Ensembl

ENSG00000038945

Chromosome

8

Canonical length

451 aa

Protein class

Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Quaternary structure

Homotrimer

OverviewNCBI Gene

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>P21757|MSR1
     1  MEQWDHFHNQ QEDTDSCSES VKFDARSMTA LLPPNPKNSP SLQEKLKSFK AALIALYLLV
    61  FAVLIPLIGI VAAQLLKWET KNCSVSSTNA NDITQSLTGK GNDSEEEMRF QEVFMEHMSN
   121  MEKRIQHILD MEANLMDTEH FQNFSMTTDQ RFNDILLQLS TLFSSVQGHG NAIDEISKSL
   181  ISLNTTLLDL QLNIENLNGK IQENTFKQQE EISKLEERVY NVSAEIMAMK EEQVHLEQEI
   241  KGEVKVLNNI TNDLRLKDWE HSQTLRNITL IQGPPGPPGE KGDRGPTGES GPRGFPGPIG
   301  PPGLKGDRGA IGFPGSRGLP GYAGRPGNSG PKGQKGEKGS GNTLTPFTKV RLVGGSGPHE
   361  GRVEILHSGQ WGTICDDRWE VRVGQVVCRS LGYPGVQAVH KAAHFGQGTG PIWLNEVFCF
   421  GRESSIEECK IRQWGTRACS HSEDAGVTCT L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

113 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MSR1.

Disease | AllUniProt

Conditions MSR1 is implicated in, by any mechanism.

• Prostate cancer (PC) MIM:176807
• Barrett esophagus (BE) MIM:614266

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 138 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Ovarian cancer
• BARRETT ESOPHAGUS/ESOPHAGEAL ADENOCARCINOMA
• Carcinoma of esophagus

Disease | ImmuneIEDB

Conditions an epitope on MSR1 was assayed in.

• rheumatoid arthritis B cell
• osteoarthritis B cell
• Sjogren's syndrome B cell
• systemic lupus erythematosus B cell
• ankylosing spondylitis B cell
• autoimmune disease of musculoskeletal system B cell
• psoriatic arthritis B cell
• gout B cell
• autoimmune vasculitis B cell
• pneumonia B cell
• arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.7

gnomAD pLI

0

gnomAD missense Z

-2.07

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amyloid-beta clearance
• cholesterol transport
• establishment of localization in cell
• lipoprotein transport
• negative regulation of gene expression
• phagocytosis, engulfment
• plasma lipoprotein particle clearance
• positive regulation of cholesterol storage
• positive regulation of macrophage derived foam cell differentiation
• receptor-mediated endocytosis

Molecular functions

• amyloid-beta binding
• cargo receptor activity
• low-density lipoprotein particle binding
• scavenger receptor activity

Cellular components

• collagen trimer
• endocytic vesicle membrane
• low-density lipoprotein particle
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• SRCR domain
• Collagen triple helix repeat
• SRCR-like domain superfamily
• Scavenger receptor cysteine-rich domain
• Collagen triple helix repeat (20 copies)
• Macrophage scavenger receptor, Class A-I/II
• Macrophage scavenger receptor

KeywordsUniProt

• Coiled coil
• Collagen
• Disulfide bond
• Endocytosis
• Glycoprotein
• LDL
• Membrane
• Phosphoprotein
• Receptor
• Signal-anchor
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MSR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MYO18A
• HOOK3