Seroatlas · Human Serome Atlas

SYCE1

Synaptonemal complex central element protein 1

Also known as: bA108K14.6, C10orf94, CT76, SYCE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N0S2
Gene
SYCE1
Ensembl
ENSG00000171772
Chromosome
10
Canonical length
351 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q8N0S2|SYCE1
     1  MAGRSLTSKA EPTAGAVDRA EKAGGQDTSS QKIEDLMEMV QKLQKVGSLE PRVEVLINRI
    61  NEVQQAKKKA NKDLGEARTI CEALQKELDS LHGEKVHLKE ILSKKQETLR ILRLHCQEKE
   121  SEAHRKHTML QECKERISAL NLQIEEEKNK QRQLRLAFEE QLEDLMGQHK DLWDFHMPER
   181  LAKEICALDS SKEQLLKEEK LVKATLEDVK HQLCSLCGAE GPSTLDEGLF LRSQEAAATV
   241  QLFQEEHRKA EELLAAAAQR HQQLQQKCQQ QQQKRQRLKE ELEKHGMQVP AQAQSTQEEE
   301  AGPGDVASPK PLKGERPGAA HQAGPDVLIG QEDTLHPDLS PRGFQEIKEL F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYCE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • testis: 70 nTPM
  • cerebellum: 18 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 12 nTPM
  • amygdala: 10 nTPM
  • hippocampal formation: 9.7 nTPM

Single-cell type

  • early primary spermatocytes: 511 nCPM
  • late primary spermatocytes: 262 nCPM
  • differentiating spermatogonia: 137 nCPM
  • late spermatids: 131 nCPM
  • early spermatids: 121 nCPM
  • oocytes: 51 nCPM

Immune cell

  • gdT-cell: 0.9 nTPM
  • MAIT T-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.8 nTPM
  • non-classical monocyte: 0.8 nTPM
  • T-reg: 0.7 nTPM
  • intermediate monocyte: 0.6 nTPM

Brain region

  • cerebral cortex: 20 nTPM
  • cerebellum: 17 nTPM
  • amygdala: 16 nTPM
  • white matter: 15 nTPM
  • basal ganglia: 15 nTPM
  • hippocampal formation: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SYCE1.

Disease | AllUniProt

Conditions SYCE1 is implicated in, by any mechanism.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 82 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Premature ovarian failure 12
  • Spermatogenic failure 15

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
0.21
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYCE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYCE1 as an antibody target. Whether an autoantibody or antibody against SYCE1 could matter depends on whether native SYCE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYCE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYCE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYCE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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