Seroatlas · Human Serome Atlas

TESC

Calcineurin B homologous protein 3

Also known as: CHP3, CHP3_HUMAN, FLJ20607, TSC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BS2
Gene: TESC
Ensembl: ENSG00000088992
Chromosome: 12
Canonical length: 214 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables calcium ion binding activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; positive regulation of myeloid cell differentiation; and positive regulation of sodium:proton antiporter activity. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q96BS2|TESC
     1  MGAAHSASEE VRELEGKTGF SSDQIEQLHR RFKQLSGDQP TIRKENFNNV PDLELNPIRS
    61  KIVRAFFDNR NLRKGPSGLA DEINFEDFLT IMSYFRPIDT TMDEEQVELS RKEKLRFLFH
   121  MYDSDSDGRI TLEEYRNVVE ELLSGNPHIE KESARSIADG AMMEAASVCM GQMEPDQVYE
   181  GITFEDFLKI WQGIDIETKM HVRFLNMETM ALCH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TESC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 311 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 311 nTPM
stomach: 131 nTPM
epididymis: 115 nTPM
bone marrow: 112 nTPM
pancreas: 101 nTPM
basal ganglia: 83 nTPM

Single-cell type

late spermatids: 562 nCPM
salivary acinar cells: 449 nCPM
urothelial cells: 390 nCPM
pancreatic duct cells: 305 nCPM
foveolar cells: 279 nCPM
oocytes: 272 nCPM

Immune cell

non-classical monocyte: 262 nTPM
intermediate monocyte: 68 nTPM
eosinophil: 52 nTPM
classical monocyte: 51 nTPM
myeloid DC: 36 nTPM
total PBMC: 19 nTPM

Brain region

basal ganglia: 53 nTPM
hippocampal formation: 31 nTPM
cerebral cortex: 27 nTPM
white matter: 15 nTPM
pons: 14 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.11
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TESC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TESC as an antibody target. Whether an autoantibody or antibody against TESC could matter depends on whether native TESC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TESC is annotated at the cell surface, where native TESC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TESC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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