GTF3C6

Protein identityUniProt · HPA

UniProt accession

Q969F1

Gene

GTF3C6

Ensembl

ENSG00000155115

Chromosome

6

Canonical length

213 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q969F1|GTF3C6
     1  MAAAADERSP EDGEDEEEEE QLVLVELSGI IDSDFLSKCE NKCKVLGIDT ERPILQVDSC
    61  VFAGEYEDTL GTCVIFEENV EHADTEGNNK TVLKYKCHTM KKLSMTRTLL TEKKEGEENI
   121  GGVEWLQIKD NDFSYRPNMI CNFLHENEDE EVVASAPDKS LELEEEEIQM NDSSNLSCEQ
   181  EKPMHLEIED SGPLIDIPSE TEGSVFMETQ MLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTF3C6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

217 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.18

gnomAD pLI

0

gnomAD missense Z

0.43

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 5S class rRNA transcription by RNA polymerase III
• transcription by RNA polymerase III
• tRNA transcription by RNA polymerase III

Molecular functions

• DNA binding
• RNA polymerase III general transcription initiation factor activity

Cellular components

• nuclear body
• nucleoplasm
• transcription factor TFIIIC complex

Protein domainsUniProt · Pfam · InterPro

• Transcription factor TFIIIC, triple barrel domain
• TFIIIC subunit GTF3C6-like
• TFIIIC subunit triple barrel domain

KeywordsUniProt

• Acetylation
• DNA-binding
• Nucleus
• Phosphoprotein
• Transcription

InteractionsUniProt · HPA

Protein binding partners of GTF3C6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GTF3C4
• GTF3C5