Seroatlas · Human Serome Atlas

GTF3C3

General transcription factor 3C polypeptide 3

Also known as: TF3C3_HUMAN, TFIIIC102, TFiiiC2-102

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5Q9
Gene
GTF3C3
Ensembl
ENSG00000119041
Chromosome
2
Canonical length
886 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Nucleoli fibrillar center

OverviewNCBI Gene

The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

886 residues, UniProt reviewed canonical sequence.

>Q9Y5Q9|GTF3C3
     1  MSGFSPELID YLEGKISFEE FERRREERKT REKKSLQEKG KLSAEENPDD SEVPSSSGIN
    61  STKSQDKDVN EGETSDGVRK SVHKVFASML GENEDDEEEE EEEEEEEEEE ETPEQPTAGD
   121  VFVLEMVLNR ETKKMMKEKR PRSKLPRALR GLMGEANIRF ARGEREEAIL MCMEIIRQAP
   181  LAYEPFSTLA MIYEDQGDME KSLQFELIAA HLNPSDTEEW VRLAEMSLEQ DNIKQAIFCY
   241  TKALKYEPTN VRYLWERSSL YEQMGDHKMA MDGYRRILNL LSPSDGERFM QLARDMAKSY
   301  YEANDVTSAI NIIDEAFSKH QGLVSMEDVN IAAELYISNK QYDKALEIIT DFSGIVLEKK
   361  TSEEGTSEEN KAPENVTCTI PDGVPIDITV KLMVCLVHLN ILEPLNPLLT TLVEQNPEDM
   421  GDLYLDVAEA FLDVGEYNSA LPLLSALVCS ERYNLAVVWL RHAECLKALG YMERAAESYG
   481  KVVDLAPLHL DARISLSTLQ QQLGQPEKAL EALEPMYDPD TLAQDANAAQ QELKLLLHRS
   541  TLLFSQGKMY GYVDTLLTML AMLLKVAMNR AQVCLISSSK SGERHLYLIK VSRDKISDSN
   601  DQESANCDAK AIFAVLTSVL TKDDWWNLLL KAIYSLCDLS RFQEAELLVD SSLEYYSFYD
   661  DRQKRKELEY FGLSAAILDK NFRKAYNYIR IMVMENVNKP QLWNIFNQVT MHSQDVRHHR
   721  FCLRLMLKNP ENHALCVLNG HNAFVSGSFK HALGQYVQAF RTHPDEPLYS FCIGLTFIHM
   781  ASQKYVLRRH ALIVQGFSFL NRYLSLRGPC QESFYNLGRG LHQLGLIHLA IHYYQKALEL
   841  PPLVVEGIEL DQLDLRRDIA YNLSLIYQSS GNTGMAQTLL YTYCSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTF3C3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 29 nTPM
  • lymph node: 17 nTPM
  • retina: 16 nTPM
  • skin: 16 nTPM
  • gallbladder: 16 nTPM
  • breast: 14 nTPM

Single-cell type

  • early primary spermatocytes: 56 nCPM
  • corticotrophs: 52 nCPM
  • thyrotrophs: 49 nCPM
  • adrenal cortex cells: 47 nCPM
  • erythrocyte progenitors: 46 nCPM
  • choroid plexus epithelial cells: 46 nCPM

Immune cell

  • basophil: 8.9 nTPM
  • naive B-cell: 6.3 nTPM
  • non-classical monocyte: 5.6 nTPM
  • memory B-cell: 4.9 nTPM
  • NK-cell: 4.6 nTPM
  • classical monocyte: 4.5 nTPM

Brain region

  • white matter: 54 nTPM
  • choroid plexus: 48 nTPM
  • pons: 46 nTPM
  • cerebellum: 46 nTPM
  • cerebral cortex: 40 nTPM
  • hypothalamus: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GTF3C3.

Disease | AllUniProt

Conditions GTF3C3 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures (NEDFBS) MIM:621201

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 124 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
2.57
DepMap mean gene effect
-0.69
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GTF3C3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTF3C3 as an antibody target. Whether an autoantibody or antibody against GTF3C3 could matter depends on whether native GTF3C3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTF3C3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTF3C3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GTF3C3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...