Seroatlas · Human Serome Atlas

GTF3C2

General transcription factor 3C polypeptide 2

Also known as: KIAA0011, TF3C2_HUMAN, TFIIIC110

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUA4
Gene: GTF3C2
Ensembl: ENSG00000115207
Chromosome: 2
Canonical length: 911 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA polymerase III general transcription initiation factor activity. Contributes to DNA binding activity. Involved in transcription by RNA polymerase III. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

911 residues, UniProt reviewed canonical sequence.

>Q8WUA4|GTF3C2
     1  MDTCGVGYVA LGEAGPVGNM TVVDSPGQEV LNQLDVKTSS EMTSAEASVE MSLPTPLPGF
    61  EDSPDQRRLP PEQESLSRLE QPDLSSEMSK VSKPRASKPG RKRGGRTRKG PKRPQQPNPP
   121  SAPLVPGLLD QSNPLSTPMP KKRGRKSKAE LLLLKLSKDL DRPESQSPKR PPEDFETPSG
   181  ERPRRRAAQV ALLYLQELAE ELSTALPAPV SCPEGPKVSS PTKPKKIRQP AACPGGEEVD
   241  GAPRDEDFFL QVEAEDVEES EGPSESSSEP EPVVPRSTPR GSTSGKQKPH CRGMAPNGLP
   301  NHIMAPVWKC LHLTKDFREQ KHSYWEFAEW IPLAWKWHLL SELEAAPYLP QEEKSPLFSV
   361  QREGLPEDGT LYRINRFSSI TAHPERWDVS FFTGGPLWAL DWCPVPEGAG ASQYVALFSS
   421  PDMNETHPLS QLHSGPGLLQ LWGLGTLQQE SCPGNRAHFV YGIACDNGCI WDLKFCPSGA
   481  WELPGTPRKA PLLPRLGLLA LACSDGKVLL FSLPHPEALL AQQPPDAVKP AIYKVQCVAT
   541  LQVGSMQATD PSECGQCLSL AWMPTRPHQH LAAGYYNGMV VFWNLPTNSP LQRIRLSDGS
   601  LKLYPFQCFL AHDQAVRTLQ WCKANSHFLV SAGSDRKIKF WDLRRPYEPI NSIKRFLSTE
   661  LAWLLPYNGV TVAQDNCYAS YGLCGIHYID AGYLGFKAYF TAPRKGTVWS LSGSDWLGTI
   721  AAGDISGELI AAILPDMALN PINVKRPVER RFPIYKADLI PYQDSPEGPD HSSASSGVPN
   781  PPKARTYTET VNHHYLLFQD TDLGSFHDLL RREPMLRMQE GEGHSQLCLD RLQLEAIHKV
   841  RFSPNLDSYG WLVSGGQSGL VRIHFVRGLA SPLGHRMQLE SRAHFNAMFQ PSSPTRRPGF
   901  SPTSHRLLPT P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTF3C2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

esophagus: 34 nTPM
parathyroid gland: 32 nTPM
tonsil: 32 nTPM
skin: 30 nTPM
pancreas: 29 nTPM
skeletal muscle: 27 nTPM

Single-cell type

early spermatids: 206 nCPM
late spermatids: 117 nCPM
myonuclei: 75 nCPM
cone photoreceptor cells: 66 nCPM
rod photoreceptor cells: 54 nCPM
podocytes: 53 nCPM

Immune cell

basophil: 29 nTPM
non-classical monocyte: 20 nTPM
total PBMC: 17 nTPM
classical monocyte: 17 nTPM
eosinophil: 15 nTPM
MAIT T-cell: 15 nTPM

Brain region

white matter: 50 nTPM
cerebellum: 49 nTPM
choroid plexus: 46 nTPM
cerebral cortex: 41 nTPM
thalamus: 40 nTPM
medulla oblongata: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 2.29
DepMap mean gene effect: -0.9
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA polymerase III general transcription initiation factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
General transcription factor 3C component

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GTF3C2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTF3C2 as an antibody target. Whether an autoantibody or antibody against GTF3C2 could matter depends on whether native GTF3C2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTF3C2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTF3C2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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