Seroatlas · Human Serome Atlas

TRMT10C

tRNA methyltransferase 10 homolog C

Also known as: FLJ20432, MRPP1, RG9MTD1, TM10C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L0Y3
Gene: TRMT10C
Ensembl: ENSG00000174173
Chromosome: 3
Canonical length: 403 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q7L0Y3|TRMT10C
     1  MAAFLKMSVS VNFFRPFTRF LVPFTLHRKR NNLTILQRYM SSKIPAVTYP KNESTPPSEE
    61  LELDKWKTTM KSSVQEECVS TISSSKDEDP LAATREFIEM WRLLGREVPE HITEEELKTL
   121  MECVSNTAKK KYLKYLYTKE KVKKARQIKK EMKAAAREEA KNIKLLETTE EDKQKNFLFL
   181  RLWDRNMDIA MGWKGAQAMQ FGQPLVFDMA YENYMKRKEL QNTVSQLLES EGWNRRNVDP
   241  FHIYFCNLKI DGALHRELVK RYQEKWDKLL LTSTEKSHVD LFPKDSIIYL TADSPNVMTT
   301  FRHDKVYVIG SFVDKSMQPG TSLAKAKRLN LATECLPLDK YLQWEIGNKN LTLDQMIRIL
   361  LCLKNNGNWQ EALQFVPKRK HTGFLEISQH SQEFINRLKK AKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT10C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

tongue: 28 nTPM
skeletal muscle: 26 nTPM
urinary bladder: 25 nTPM
liver: 24 nTPM
heart muscle: 20 nTPM
breast: 19 nTPM

Single-cell type

esophageal basal cells: 120 nCPM
suprabasal keratinocytes: 111 nCPM
erythrocyte progenitors: 107 nCPM
basal keratinocytes: 103 nCPM
late primary spermatocytes: 101 nCPM
esophageal suprabasal cells: 92 nCPM

Immune cell

basophil: 57 nTPM
memory B-cell: 36 nTPM
naive CD4 T-cell: 35 nTPM
naive B-cell: 34 nTPM
naive CD8 T-cell: 33 nTPM
MAIT T-cell: 30 nTPM

Brain region

cerebellum: 13 nTPM
cerebral cortex: 13 nTPM
choroid plexus: 12 nTPM
hypothalamus: 11 nTPM
pons: 11 nTPM
basal ganglia: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRMT10C.

Disease | AllUniProt

Conditions TRMT10C is implicated in, by any mechanism.

Combined oxidative phosphorylation deficiency 30 (COXPD30) MIM:616974

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 99 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Combined oxidative phosphorylation defect type 30
Mitochondrial disease

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.77
DepMap mean gene effect: -0.43
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding
RNA binding
tRNA (guanosine(9)-N1)-methyltransferase activity
tRNA binding
tRNA (adenine(9)-N1)-methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

tRNA (guanine(9)-N1)-methyltransferase, eukaryotic
tRNA methyltransferase TRM10-type domain
tRNA methyltransferase TRM10-type domain superfamily
tRNA methyltransferase 10 homolog C, TRM10-type domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRMT10C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT10C as an antibody target. Whether an autoantibody or antibody against TRMT10C could matter depends on whether native TRMT10C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT10C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT10C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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