Seroatlas · Human Serome Atlas

TCP10L

T-complex protein 10A homolog 1

Also known as: PRED77, TCP1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDR4
Gene: TCP10L
Ensembl: ENSG00000242220
Chromosome: 21
Canonical length: 215 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>Q8TDR4|TCP10L
     1  MLAGQLEARD PKEGTHPEDP CPGAGAVMEK TAVAAEVLTE DCNTGEMPPL QQQIIRLHQE
    61  LGRQKSLWAD VHGKLRSHID ALREQNMELR EKLRALQLQR WKARKKSAAS PHAGQESHTL
   121  ALEPAFGKIS PLSADEETIP KYAGHKNQSA TLLGQRSSSN NSAPPKPMSL KIERISSWKT
   181  PPQENRDKNL SRRRQDRRAT PTGRPTPCAE RRGGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCP10L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 143 nTPM

Expression across tissuesHPA

Tissue

testis: 143 nTPM
liver: 18 nTPM
epididymis: 1.7 nTPM
retina: 1.7 nTPM
bone marrow: 1.4 nTPM
cerebral cortex: 1.2 nTPM

Single-cell type

ependymal cells: 141 nCPM
bergmann glia: 88 nCPM
brain inhibitory neurons: 66 nCPM
brain excitatory neurons: 65 nCPM
choroid plexus epithelial cells: 54 nCPM
astrocytes: 51 nCPM

Immune cell

intermediate monocyte: 0.2 nTPM
myeloid DC: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
neutrophil: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 11 nTPM
cerebral cortex: 8.3 nTPM
white matter: 7.9 nTPM
hippocampal formation: 6.8 nTPM
basal ganglia: 6.6 nTPM
medulla oblongata: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

TCP10L/CENPJ

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCP10L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCP10L as an antibody target. Whether an autoantibody or antibody against TCP10L could matter depends on whether native TCP10L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCP10L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCP10L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...