INSC

Protein identityUniProt · HPA

UniProt accession

Q1MX18

Gene

INSC

Ensembl

ENSG00000188487

Chromosome

11

Canonical length

579 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q1MX18|INSC
     1  MRRPPGNGEA ASEGPGGWGL WGVQESRRLC CAGHDRCKQA LLQIGINMMA LPGGRHLDSV
    61  TLPGQRLHLM QVDSVQRWME DLKLMTECEC MCVLQAKPIS LEEDAQGDLI LAGGPGPGDP
   121  LQLLLKRGWV ISTELRRIGQ KLAQDRWARV HSMSVRLTCH ARSMVSEYSA VSRNSLKEMG
   181  EIEKLLMEKC SELSAVTERC LQVENEHVLK SMKACVSETL SMLGQHFGQL LELALTREVQ
   241  ALVRKIDASD NIYTTESTTG NLFSLTQEGA PLCRIIAKEG GVVALFKVCR QDSFRCLYPQ
   301  ALRTLASICC VEEGVHQLEK VDGVLCLADI LTDNSHSEAT RAEAAAVVAQ VTSPHLPVTQ
   361  HLSSFLESME EIVTALVKLC QEASSGEVFL LASAALANIT FFDTMACEML LQLNAIRVLL
   421  EACSDKQRVD TPYTRDQIVT ILANMSVLEQ CASDIIQENG VQLIMGMLSE KPRSGTPAEV
   481  AACERVQQKA AVTLARLSRD PDVAREAVRL SCMSRLIELC RSPSERNSSD AVLVACLAAL
   541  RRLAGVCPEG LQDSDFQQLV QPRLVDSFLL CSNMEESFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INSC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

24 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.32

gnomAD pLI

0

gnomAD missense Z

-0.19

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apical protein localization
• asymmetric cell division
• cell differentiation
• nervous system development
• regulation of asymmetric cell division
• regulation of protein stability

Molecular functions

• cytoskeletal anchor activity
• protein domain specific binding
• protein-macromolecule adaptor activity

Cellular components

• apical cortex
• plasma membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Armadillo
• Armadillo-like helical
• Armadillo-type fold
• Protein inscuteable homologue, LGN-binding domain
• Protein inscuteable homologue, LGN-binding domain superfamily
• Inscuteable
• Protein inscuteable homologue, C-terminal domain
• Inscuteable LGN-binding domain
• Protein inscuteable C-terminal

KeywordsUniProt

• Cytoplasm
• Developmental protein
• Differentiation
• Neurogenesis

InteractionsUniProt · HPA

Protein binding partners of INSC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GPSM2