Seroatlas · Human Serome Atlas

FRMPD1

FERM and PDZ domain-containing protein 1

Also known as: FRMD2, FRPD1_HUMAN, KIAA0967

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5SYB0
Gene
FRMPD1
Ensembl
ENSG00000070601
Chromosome
9
Canonical length
1578 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in establishment of protein localization to membrane and regulation of G protein-coupled receptor signaling pathway. Located in cell cortex and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1578 residues, UniProt reviewed canonical sequence.

>Q5SYB0|FRMPD1
     1  MEELETSLFQ TRKAHRIEQM VARWLRRSRD SSARAKVAAA DGPARNPTQT LIPVRHTVKI
    61  DKDTLLQDYG FHISESLPLT VVAVTAGGSA HGKLFPGDQI LQMNNEPAED LSWERAVDIL
   121  REAEDSLSIT VVRCTSGVPK SSFLTEEKRA RLKTNPVKVH FAEEVLISGH SQGNSLLCMP
   181  NVLKLYLENG QTKAFKFEAN TTVKDIILTV KEKLSIRSIE YFALALEEQY SISRLHLLHE
   241  EELIQQVVER EESHDYRCLF RVCFVPKDPL DLLKEDPVAF EYLYLQSCSD VLQERFAVEM
   301  KCSSALRLAA LHIQERIYAC AQPQKISLKY IEKDWGIENF ISPTLLRNMK GKDIKKAISF
   361  HMKRNQNLLE PRQKQLISAA QLRLNYLQIL GELKTYGGRI FNATLMLQDR ESYIALLVGA
   421  KYGISQVINS KLNIMSTLAE FANISRVELT EESEKVSVVK VYLQDVKVLT LLLESNSAKD
   481  LACLIAGYYR LLVDPVTSIF LWPGNKQQAH RVSAEEGYES RACSDSEESS EVDCVLEPLS
   541  DRRLVKLAPC RSLIKEEQPP GNSPTPEVAR RGPSTCGASS TTDSAESEAS DSANTESRGY
   601  RTSGSSESMD ALEEDDLDTC SSSRSTFFHF GSPGLAESID SDSQEERSGI ETSGFLCLLD
   661  LAQRANPQCQ KTEFSESAAL ETFGWAPELS TVRLDPRLYE GSHADYYSLC SSVSPASYLS
   721  DSSESTASRQ GGAPPAWGQQ GWTEAQPSSM LEPLALHPPL AFEDGSSDEE YYDAADKLTP
   781  PGPPSGPRDV STAEPSATSL QNKASTSSPE NSLPCGPDGR QPSRRGGVKK YAKTLRKRRS
   841  FLQTDYTSQV SFPLVPSASL ESVDDVCYYD REPYLALGAP SPTVSSLQDM QGEPGLLETK
   901  ALGLLAPLRE TKSTNPASRV MEMEPETMET KSVIDSRVSS ISAIRFRIDP NNKENSGVVP
   961  AASSSASTPH CSNPGSSGPD TAQARPSQIL PLSQDLDGIA PKEPTIEHGD SSFSLSSGDP
  1021  NPDRACLASN PGLNNVSQGD TLELQLEPHV QLEMGLESFC TNHIQETAPK YTEPLLSPRD
  1081  EPRSDECGIN PGEKIASIPT KEEPQGQLSL ERDREVTNKN GTNVFQEESR KDSGDSPGDV
  1141  SNNVSQTLDI SSPAGKIVTS LSLDAPVTGT EQIPPHPPRD PQGQSREPPG QGCQAQEQKL
  1201  FVELDLDPDF FLGKQTVSPA VPPEGIKAEA PNHVTGQDIA PRDSPEWVCF NPEPSLPEPL
  1261  PCPQEDPHLE TSNHCLLSEG KSDSSSICLS AEKSFLCFAP ESHPEVSASL RVATSLGFAG
  1321  MNEMVAPRIG MDQCSCQFSY ATCFRGPQPE TEEEDRDLEA HPMAPLTSPP SAGSPVVLPW
  1381  RPARAHSCTT APLSRKSHIW PEYCSRALRQ LKATPASTPE GFIQLMESLL ELQDILETSW
  1441  GVGNKHPPEK CTWHFTESRS RLCMGSQKLL SSCRHVIRMD QSPEEMQGAV RDTFQHLVQL
  1501  AGLCFQFTDC SRCSARHREA AGNLRDVVYT YHQFIEAAKS TCERGYHDLS VKLLARQCTA
  1561  LTAAVFCLTQ KFRASTAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRMPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • retina: 64 nTPM
  • testis: 9.1 nTPM
  • skin: 5.9 nTPM
  • skeletal muscle: 3.9 nTPM
  • salivary gland: 3.8 nTPM
  • bone marrow: 2.1 nTPM

Single-cell type

  • cone photoreceptor cells: 542 nCPM
  • rod photoreceptor cells: 410 nCPM
  • sertoli cells: 200 nCPM
  • retinal bipolar cells: 144 nCPM
  • salivary acinar cells: 39 nCPM
  • retinal ganglion cells: 31 nCPM

Immune cell

  • basophil: 3.4 nTPM
  • NK-cell: 1.5 nTPM
  • neutrophil: 1.1 nTPM
  • naive B-cell: 0.5 nTPM
  • classical monocyte: 0.4 nTPM
  • eosinophil: 0.4 nTPM

Brain region

  • thalamus: 20 nTPM
  • midbrain: 18 nTPM
  • white matter: 17 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 16 nTPM
  • medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
0.67
DepMap mean gene effect
-0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRMPD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRMPD1 as an antibody target. Whether an autoantibody or antibody against FRMPD1 could matter depends on whether native FRMPD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRMPD1 is annotated at the cell surface, where native FRMPD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FRMPD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FRMPD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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