Frizzled/Smoothened, 7TM

Definition

This domain is the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane α-helices. Proteins related to Drosophila frizzled ([swissprot:P18537]) are receptors for Wnt (mediating the beta-catenin signalling pathway) PMID:8717036, but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly α-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding PMID:15239825. The smoothened receptor mediates hedgehog signalling PMID:9811578.

11 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (11 proteins: gene, accession, name)

• FZD1
• FZD10
• FZD2
• FZD3
• FZD4
• FZD5
• FZD6
• FZD7
• FZD8
• FZD9
• SMO