Seroatlas · Human Serome Atlas

WNT7A

Protein Wnt-7a

Also known as: Wnt-7a, WNT7A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00755
Gene
WNT7A
Ensembl
ENSG00000154764
Chromosome
3
Canonical length
349 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>O00755|WNT7A
     1  MNRKARRCLG HLFLSLGMVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA ICQSRPDAII
    61  VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG SREAAFTYAI IAAGVAHAIT
   121  AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG GCSADIRYGI GFAKVFVDAR EIKQNARTLM
   181  NLHNNEAGRK ILEENMKLEC KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP
   241  VRASRNKRPT FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ
   301  ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WNT7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
3.9 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 3.9 nTPM
  • cerebral cortex: 3.8 nTPM
  • basal ganglia: 3.1 nTPM
  • placenta: 2.5 nTPM
  • gallbladder: 2.2 nTPM
  • lung: 1.9 nTPM

Single-cell type

  • syncytiotrophoblasts: 219 nCPM
  • extravillous trophoblasts: 210 nCPM
  • cytotrophoblasts: 88 nCPM
  • migrating cytotrophoblasts: 77 nCPM
  • alveolar cells type 1: 44 nCPM
  • endometrial luminal cells: 40 nCPM

Immune cell

  • memory CD4 T-cell: 1.7 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • total PBMC: 0.2 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • medulla oblongata: 11 nTPM
  • cerebral cortex: 7.8 nTPM
  • amygdala: 7.6 nTPM
  • spinal cord: 7.2 nTPM
  • basal ganglia: 6.5 nTPM
  • white matter: 5.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WNT7A.

Disease | AllUniProt

Conditions WNT7A is implicated in, by any mechanism.

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 131 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Schinzel phocomelia syndrome
  • Fuhrmann syndrome
  • Santos syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.04
gnomAD missense Z
1.34
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WNT7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WNT7A as an antibody target. Whether an autoantibody or antibody against WNT7A could matter depends on whether native WNT7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WNT7A is annotated as secreted, so native WNT7A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WNT7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WNT7A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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