Seroatlas · Human Serome Atlas

ZNRF3

E3 ubiquitin-protein ligase ZNRF3

Also known as: BK747E2.3, FLJ22057, KIAA1133, RNF203, ZNRF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULT6
Gene
ZNRF3
Ensembl
ENSG00000183579
Chromosome
22
Canonical length
936 aa
Protein class
Enzymes, Predicted membrane proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

936 residues, UniProt reviewed canonical sequence.

>Q9ULT6|ZNRF3
     1  MRPRSGGRPG ATGRRRRRLR RRPRGLRCSR LPPPPPLPLL LGLLLAAAGP GAARAKETAF
    61  VEVVLFESSP SGDYTTYTTG LTGRFSRAGA TLSAEGEIVQ MHPLGLCNNN DEEDLYEYGW
   121  VGVVKLEQPE LDPKPCLTVL GKAKRAVQRG ATAVIFDVSE NPEAIDQLNQ GSEDPLKRPV
   181  VYVKGADAIK LMNIVNKQKV ARARIQHRPP RQPTEYFDMG IFLAFFVVVS LVCLILLVKI
   241  KLKQRRSQNS MNRLAVQALE KMETRKFNSK SKGRREGSCG ALDTLSSSST SDCAICLEKY
   301  IDGEELRVIP CTHRFHRKCV DPWLLQHHTC PHCRHNIIEQ KGNPSAVCVE TSNLSRGRQQ
   361  RVTLPVHYPG RVHRTNAIPA YPTRTSMDSH GNPVTLLTMD RHGEQSLYSP QTPAYIRSYP
   421  PLHLDHSLAA HRCGLEHRAY SPAHPFRRPK LSGRSFSKAA CFSQYETMYQ HYYFQGLSYP
   481  EQEGQSPPSL APRGPARAFP PSGSGSLLFP TVVHVAPPSH LESGSTSSFS CYHGHRSVCS
   541  GYLADCPGSD SSSSSSSGQC HCSSSDSVVD CTEVSNQGVY GSCSTFRSSL SSDYDPFIYR
   601  SRSPCRASEA GGSGSSGRGP ALCFEGSPPP EELPAVHSHG AGRGEPWPGP ASPSGDQVST
   661  CSLEMNYSSN SSLEHRGPNS STSEVGLEAS PGAAPDLRRT WKGGHELPSC ACCCEPQPSP
   721  AGPSAGAAGS STLFLGPHLY EGSGPAGGEP QSGSSQGLYG LHPDHLPRTD GVKYEGLPCC
   781  FYEEKQVARG GGGGSGCYTE DYSVSVQYTL TEEPPPGCYP GARDLSQRIP IIPEDVDCDL
   841  GLPSDCQGTH SLGSWGGTRG PDTPRPHRGL GATREEERAL CCQARALLRP GCPPEEAGAV
   901  RANFPSALQD TQESSTTATE AAGPRSHSAD SSSPGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNRF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 13 nTPM
  • cerebral cortex: 9.7 nTPM
  • parathyroid gland: 8.2 nTPM
  • basal ganglia: 8.1 nTPM
  • kidney: 7.7 nTPM
  • seminal vesicle: 7.3 nTPM

Single-cell type

  • podocytes: 1,196 nCPM
  • astrocytes: 631 nCPM
  • loop of henle epithelial cells: 400 nCPM
  • renal collecting duct intercalated cells: 306 nCPM
  • renal collecting duct principal cells: 292 nCPM
  • proximal tubule cells: 290 nCPM

Immune cell

  • NK-cell: 0.3 nTPM
  • basophil: 0.2 nTPM
  • eosinophil: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • thalamus: 39 nTPM
  • medulla oblongata: 39 nTPM
  • cerebral cortex: 38 nTPM
  • hippocampal formation: 36 nTPM
  • amygdala: 34 nTPM
  • basal ganglia: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNRF3.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 166 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • ZNRF3-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
0.98
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNRF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNRF3 as an antibody target. Whether an autoantibody or antibody against ZNRF3 could matter depends on whether native ZNRF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNRF3 is annotated at the cell surface, where native ZNRF3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZNRF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNRF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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