Seroatlas · Human Serome Atlas

WNT2B

Protein Wnt-2b

Also known as: WNT13, WNT2B_HUMAN, XWNT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q93097
Gene
WNT2B
Ensembl
ENSG00000134245
Chromosome
1
Canonical length
391 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Vesicles
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>Q93097|WNT2B
     1  MLRPGGAEEA AQLPLRRASA PVPVPSPAAP DGSRASARLG LACLLLLLLL TLPARVDTSW
    61  WYIGALGARV ICDNIPGLVS RQRQLCQRYP DIMRSVGEGA REWIRECQHQ FRHHRWNCTT
   121  LDRDHTVFGR VMLRSSREAA FVYAISSAGV VHAITRACSQ GELSVCSCDP YTRGRHHDQR
   181  GDFDWGGCSD NIHYGVRFAK AFVDAKEKRL KDARALMNLH NNRCGRTAVR RFLKLECKCH
   241  GVSGSCTLRT CWRALSDFRR TGDYLRRRYD GAVQVMATQD GANFTAARQG YRRATRTDLV
   301  YFDNSPDYCV LDKAAGSLGT AGRVCSKTSK GTDGCEIMCC GRGYDTTRVT RVTQCECKFH
   361  WCCAVRCKEC RNTVDVHTCK APKKAEWLDQ T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WNT2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 13 nTPM
  • skin: 10 nTPM
  • ovary: 9.5 nTPM
  • vagina: 8.1 nTPM
  • cervix: 6.7 nTPM
  • lung: 5.8 nTPM

Single-cell type

  • peritubular myoid cells: 194 nCPM
  • microglia: 150 nCPM
  • vascular endothelial cells: 97 nCPM
  • endometrial secretory cells: 93 nCPM
  • leydig cells: 83 nCPM
  • endometrial luminal cells: 78 nCPM

Immune cell

  • naive B-cell: 0.2 nTPM
  • basophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • cerebral cortex: 13 nTPM
  • basal ganglia: 11 nTPM
  • white matter: 7.7 nTPM
  • cerebellum: 7.4 nTPM
  • choroid plexus: 7.4 nTPM
  • amygdala: 7.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WNT2B.

Disease | AllUniProt

Conditions WNT2B is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 207 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Diarrhea 9
  • Failure to thrive in infancy
  • Diarrhea
  • Impaired feeding ability
  • Chronic diarrhea

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.04
gnomAD missense Z
1.51
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WNT2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WNT2B as an antibody target. Whether an autoantibody or antibody against WNT2B could matter depends on whether native WNT2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WNT2B is annotated as secreted, so native WNT2B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WNT2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WNT2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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