Frizzled/Smoothened family membrane region

Definition

This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled ([swissprot:P18537]) are receptors for Wnt (mediating the beta-catenin signalling pathway) PMID:8717036, but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding PMID:15239825. The smoothened receptor mediates hedgehog signalling PMID:9811578.

11 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (11 proteins: gene, accession, name)

• FZD1
• FZD10
• FZD2
• FZD3
• FZD4
• FZD5
• FZD6
• FZD7
• FZD8
• FZD9
• SMO