VEGFB
Vascular endothelial growth factor B
Also known as: VEGFB_HUMAN, VEGFL, VRF
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P49765
- Gene
- VEGFB
- Ensembl
- ENSG00000173511
- Chromosome
- 11
- Canonical length
- 207 aa
- Protein class
- Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
- Secretome location
- Secreted to blood
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Canonical amino-acid sequenceUniProt
207 residues, UniProt reviewed canonical sequence.
>P49765|VEGFB
1 MSPLLRRLLL AALLQLAPAQ APVSQPDAPG HQRKVVSWID VYTRATCQPR EVVVPLTVEL
61 MGTVAKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ ILMIRYPSSQ LGEMSLEEHS
121 QCECRPKKKD SAVKPDRAAT PHHRPQPRSV PGWDSAPGAP SPADITHPTP APGPSAHAAP
181 STTSALTPGP AAAAADAAAS SVAKGGALocalizationUniProt · AlphaFold · HPA
Whether an antibody against VEGFB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 115 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 115 nTPM
- adipose tissue: 98 nTPM
- blood vessel: 85 nTPM
- breast: 72 nTPM
- skeletal muscle: 70 nTPM
- colon: 69 nTPM
Single-cell type
- pdcs: 310 nCPM
- retinal pigment epithelial cells: 149 nCPM
- breast lactating cells: 119 nCPM
- peritubular myoid cells: 109 nCPM
- breast myoepithelial cells: 107 nCPM
- smooth muscle cells: 105 nCPM
Immune cell
- plasmacytoid DC: 31 nTPM
- memory B-cell: 3 nTPM
- naive B-cell: 2.5 nTPM
- naive CD8 T-cell: 1.6 nTPM
- gdT-cell: 0.9 nTPM
- memory CD8 T-cell: 0.9 nTPM
Brain region
- medulla oblongata: 104 nTPM
- thalamus: 96 nTPM
- basal ganglia: 94 nTPM
- choroid plexus: 89 nTPM
- midbrain: 88 nTPM
- pons: 83 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.71
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cardiac muscle contraction
- coronary vasculature development
- induction of positive chemotaxis
- negative regulation of apoptotic process
- negative regulation of gene expression
- negative regulation of neuron apoptotic process
- positive regulation of cell division
- positive regulation of cell population proliferation
- positive regulation of endothelial cell proliferation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of mast cell chemotaxis
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- positive regulation of vascular wound healing
- protein O-linked glycosylation
- response to hypoxia
- sprouting angiogenesis
- vascular endothelial growth factor receptor signaling pathway
- vascular endothelial growth factor signaling pathway
Molecular functions
- chemoattractant activity
- growth factor activity
- heparin binding
- identical protein binding
- vascular endothelial growth factor receptor 1 binding
- vascular endothelial growth factor receptor binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of VEGFB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads VEGFB as an antibody target. Whether an autoantibody or antibody against VEGFB could matter depends on whether native VEGFB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
VEGFB is annotated as secreted, so native VEGFB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label VEGFB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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